Document Detail


Early changes with diabetes in renal medullary hemodynamics as evaluated by fiberoptic probes and BOLD magnetic resonance imaging.
MedLine Citation:
PMID:  17287645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to evaluate the influence of streptozotocin (STZ)-induced diabetes on renal outer medullary pO2 and blood flow by invasive microprobes and to demonstrate feasibility that blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) can monitor these changes.
MATERIALS AND METHODS: A total of 60 Wistar-Furth rats were used. Diabetes was induced by STZ in 48. Animals were divided into OxyLite group (n=30) and BOLD MRI groups (n=30) each with a 5 subgroups of 6 animals: control and 2, 5, 14, and 28 days after induction of diabetes. Outer renal medullary oxygen tension and blood flow were measured by the combined OxyLite/OxyFlo probes.
RESULTS: Both OxyLite and BOLD MRI showed a significant increase in the renal hypoxia levels after STZ at all time points. However, no changes were observed in the outer renal medullary oxygen tension and blood flow between diabetic and control groups.
CONCLUSIONS: These preliminary results suggest that hypoxic changes can be detected as early as 2 days in rat kidneys with diabetes by BOLD MRI and that these early changes are not dependent on blood flow.
Authors:
Elisabete Alcantara dos Santos; Lu-Ping Li; Lin Ji; Pottumarthi Vara Prasad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative radiology     Volume:  42     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-04-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetic Nephropathies / diagnosis*
Fiber Optic Technology
Kidney Medulla / blood supply*
Magnetic Resonance Imaging / instrumentation,  methods
Oxygen Consumption
Rats
Rats, Wistar
Renal Circulation / physiology*
Streptozocin
Time Factors
Grant Support
ID/Acronym/Agency:
R01 DK073973/DK/NIDDK NIH HHS; R01 DK073973-01A2/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
5W494URQ81/Streptozocin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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