Document Detail


Early changes of left ventricular geometry and deformational analysis in obese subjects without cardiovascular risk factors: a three-dimensional and speckle tracking echocardiographic study.
MedLine Citation:
PMID:  24794426     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Subclinical myocardial dysfunction has been identified in obese subjects without cardiovascular risks factors and has been defined as "obesity cardiomyopathy". We evaluated left ventricular (LV) function and geometry in obese patients by using a 3 dimensional echocardiography (3DE). We also aimed to look at the influence of ventricular geometry upon functional parameters of the LV by using 3D speckle tracking imaging (3D-STI). 30 consecutive and asymptomatic obese cases (OB group) with no comorbidities were prospectively enrolled. The control group included 30 healthy volunteers (HS group), matched for age and sex. All subjects underwent 3DE and 3D-STI. Ventricular geometry was evaluated with the LV sphericity index (LV SpI) and the LV diastolic volume to mass ratio (LV EDV/Mass ratio). LV Mass was significantly increased in OB group and the LV EDV/Mass ratio had a significantly lower mean value in this group (p < 0.001 and p = 0.002, respectively). LV SpI was significantly reduced in obese subjects (p < 0.001). A significant reduction in longitudinal (GLS), radial (GRS) and area strain (GAS) was observed in OB group (p = 0.001 for all) while circumferential mechanic (GCS) was not different between the two groups (p = 0.052). LV EDV to mass ratio was significantly related to GLS (r = -0.298, p = 0.022) and GAS (r = -0.289, p = 0.026). On multivariate analysis, GRS and GAS were independently related to LV SpI (β = 0.222, p = 0.031 and β = -0.222, p = 0.034, respectively). Geometrical and structural ventricular remodeling negatively influences functional properties of the LV in obese subjects without cardiovascular risks factors. Further studies are needed to assess the prognostic value of our findings.
Authors:
Ines Paola Monte; Sarah Mangiafico; Sergio Buccheri; Antonio Andrea Arcidiacono; Vincenzo Lavanco; Fiorella Privitera; Stefano Leggio; Wanda Deste; Corrado Tamburino
Related Documents :
23996806 - Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an ob...
11265716 - Diagnostic accuracy of derived versus standard 12-lead electrocardiograms.
15820156 - Which parameters on magnetic resonance imaging determine q waves on the electrocardiogram?
15701746 - Modified electrode placement must be recorded when performing 12-lead electrocardiograms.
8492636 - Demonstration of the myocardial salvage effect of lithospermic acid b isolated from the...
10787466 - Adverse effects of corticosteroids on the cardiovascular system.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-4
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  -     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How pervasive are circadian oscillations?
Next Document:  Circular Distribution Pattern of Plant Modulars and Endophagous Herbivory within Tree Crowns: The Im...