| Early changes in liver perfusion caused by occult metastases in rats: detection with quantitative CT. | |
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MedLine Citation:
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PMID: 11161178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine whether computed tomography (CT) can depict liver hemodynamic changes caused by occult hepatic micrometastases in rat. MATERIALS AND METHODS: Liver micrometastases (mean diameter, 500 micrometer +/- 300) were produced in seven BD IX rats by injecting 10(7) DHDK12 PROb colorectal carcinoma cells into the spleen. Macrometastases (mean diameter, 7 mm +/- 3) were produced in four other rats. Five normal rats were studied as controls. CT images were obtained every 300 msec for 30 seconds during the injection of 1 mL per kilogram of body weight of contrast medium. The time-attenuation curves of the aorta, portal vein, and liver were used to calculate liver perfusion with a deconvolution model designed for the dual blood supply. RESULTS: Micrometastases in an apparently normal liver caused a 34% decrease in portal blood flow and a 25% increase in the mean transit time for the blood to pass through the liver. These findings suggest increased resistance in the sinusoidal capillaries. Similar but greater changes were found in the macrometastases. CONCLUSION: Occult liver micrometastases in rats generate changes in liver perfusion that can be detected with CT. |
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Authors:
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C Cuenod; I Leconte; N Siauve; A Resten; C Dromain; B Poulet; F Frouin; O Clément; G Frija |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 218 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 556-61 Citation Subset: AIM; IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale (INSERM) U494, Paris, France. ca@cuenod.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media Hepatic Artery / radiography Iohexol / analogs & derivatives, diagnostic use Liver Circulation* Liver Neoplasms, Experimental / blood supply, radiography*, secondary* Male Portal Vein / radiography Rats Rats, Inbred Strains Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/iobitridol; 66108-95-0/Iohexol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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