| Early changes in cerebral sodium distribution following ischaemia monitored by 23Na magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 7968289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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23Na magnetic resonance imaging has been used in this preliminary study to investigate early changes in brain sodium signal intensity during and after cerebral ischaemia in a gerbil model. The total sodium signal in selected brain regions decreased between 15 and 30% within 4 min of the onset of ischaemia, and then remained constant throughout the ischaemic period. The same pattern was observed in the eyes. On reperfusion, there was no significant change in the sodium signal over the first 4 min, but by 8 min the signal intensity had returned to or passed through control levels in all regions measured, with the exception of the eyes. These observations are consistent with the loss and resynthesis of ATP as seen in this model, and may be reflecting the redistribution of tissue sodium resulting from energy failure and recovery. |
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Authors:
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K L Allen; A L Busza; S R Williams; S C Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 12 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 1994 |
Date Detail:
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Created Date: 1994-12-01 Completed Date: 1994-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 895-900 Citation Subset: IM |
Affiliation:
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Department of Neurochemistry, Institute of Neurology, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adenosine Triphosphate / metabolism Animals Brain / metabolism* Brain Ischemia / diagnosis, metabolism* Gerbillinae Magnetic Resonance Imaging* Male Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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