| Early changes of body composition in asymptomatic celiac disease patients. | |
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MedLine Citation:
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PMID: 8677938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIM: This is a study of patients with asymptomatic celiac disease. The aims of this study were: 1) To evaluate the nutritional status of asymptomatic patients with newly diagnosed celiac disease, and 2) to compare these findings with those of untreated/symptomatic and treated patients. MATERIAL: We examined 41 patients with celiac disease divided into three groups: a) 8 asymptomatic (diagnosed in a study of first-degree relatives of probands), b) 20 untreated/symptomatic patients, and c) 13 treated patients. Nutrition of patients from groups A and B was assessed at the time of diagnosis. METHODS: Nutritional status was evaluated by: 1) body composition (fat and lean mass) by dual energy x-ray absorptiometry (DEXA), and 2) anthropometric measurements. RESULTS: Compared with sex and age matched controls (n = 153), asymptomatic patients presented a moderate but significant reduction of the fat compartment (-29%; p < 0.001), but not of the lean-tissue mass (p = NS). Untreated/symptomatic patients showed a more severe depletion of fat (-46%; p < 0.001) and lean mass (-9.0%; p < 0.05) compared with healthy controls. Although fat mass of treated patients was significantly reduced with respect to controls (-24%; p < 0.003), lean mass was not affected. The anthropometric measurements of fat showed a significant correlation with the evaluation by DEXA (multiple regression analysis r = 0.918). CONCLUSION: Asymptomatic patients in our study with an unequivocal diagnosis of celiac disease established by mucosal biopsy exhibited a modified body composition. |
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Authors:
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R M Mazure; H Vazquez; D Gonzalez; C Mautalen; G Soifer; M Cataldi; E Mauriño; S Niveloni; A M Siccadi; D Flores; S Pedreira; L Boerr; J C Bai |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 91 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-08-15 Completed Date: 1996-08-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 726-30 Citation Subset: IM |
Affiliation:
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Centro de Osteopatías Médicas, Hospital de Clínicas, Universidad de Buenos Aires, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adipose Tissue / pathology Adult Body Composition* Body Mass Index Case-Control Studies Celiac Disease / diagnosis, diet therapy, physiopathology* Female Glutens / administration & dosage Humans Male Nutritional Status |
| Chemical | |
Reg. No./Substance:
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8002-80-0/Glutens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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