Document Detail

Early change of adenosine triphosphate levels in L5178Y cells during hyperthermia.
MedLine Citation:
PMID:  3108213     Owner:  NLM     Status:  MEDLINE    
The time course of the change of cellular ATP level was studied in L5178Y cells exposed continuously to various temperatures and compared with that of cell death determined by means of a dye-exclusion test. The ATP level first increased at all temperatures tested and then decreased at temperatures higher than 42 degrees. The onset of this decrease always preceded the beginning of cell death. The results support the idea that the cellular lethality of heat treatment is well correlated with cellular ATP content in L5178Y cells.
K Shinohara; M Kugotani; J Ishiwata; T Matsuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of cancer research : Gann     Volume:  78     ISSN:  0910-5050     ISO Abbreviation:  Jpn. J. Cancer Res.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-16     Completed Date:  1987-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8509412     Medline TA:  Jpn J Cancer Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  333-5     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / metabolism*
Cell Survival
Cells, Cultured
Hyperthermia, Induced*
Leukemia L5178 / metabolism*
Leukemia, Experimental / metabolism*
Time Factors
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

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