| Early cardiovascular involvement in patients with systemic sclerosis (SSc). | |
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MedLine Citation:
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PMID: 11859277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin, and by distinctive forms of internal organ involvement. Symptoms usually occur relatively late and are nonspecific, thus often unrecognized. The purpose of our study was to evaluate cardiac function in patients with SSc by means of non-invasive methods in order to detect early dysfunction of the cardiovascular system. MATERIAL/METHODS: A group of 22 patients with SSc was compared with a group of 22 healthy volunteers. Standard EKG, 24-hour Holter monitoring (HM), and echocardiography were performed in all subjects. RESULTS: In patients with SSc, HM revealed a tendency to tachycardia. Conduction disturbances were observed in 3 patients. In 6 patients significant ventricular arrhythmia was found. Silent ischemia episodes were detected in 6 patients. In HRV analysis, significantly lower values were detected in patients with SSc than in controls. LPs were present in one patient with SSc, and none in the control group. The mean values for QT interval did not exceed the range of normal values. No signs of systolic cardiac dysfunction were detected, while in 6 patients left ventricle diastolic dysfunction was recognized. Valvular lesions were observed in 8 patients, but only in 2 patients were they hemodynamically important. CONCLUSIONS: 24-hour Holter monitoring and echocardiography enable the early detection of cardiovascular dysfunction in patients with systemic sclerosis presenting without apparent cardiac impairment symptoms. |
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Authors:
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Jerzy Wranicz; Marzenna Zielińska; Iwona Cygankiewicz; Bozena Dziankowska-Bartkowiak; Anna Sysa-Jedrzejowska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 8 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-22 Completed Date: 2002-06-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR78-82 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Institute of Cardiology, Medical University of Łódź, ul. Sterlinga 1/3, 91-425 Łódź, Poland. holter@csk.am.lodz.pl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cardiovascular System / physiopathology*, ultrasonography Echocardiography Electrocardiography Female Humans Male Middle Aged Scleroderma, Systemic / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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