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Early brain injury following aneurysmal subarachnoid hemorrhage: emphasis on cellular apoptosis.
MedLine Citation:
PMID:  23015327     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Subarachnoid hemorrhage (SAH) due to intracranial aneurysm rupture is a complex clinical disease with high mortality and morbidity. Recent studies suggest that early brain injury (EBI) rather than vasospasm might be responsible for morbidity and mortality within 24-72 hours after SAH. The rise in intracranial pressure following SAH causes a significant drop in cerebral perfusion pressure that leads to global cerebral ischemia and initiates the acute injury cascade. Various molecular mechanisms have been shown to involve in the pathophysiology of EBI including cellular apoptosis. In this review, we summarize apoptotic molecular mechanisms involved in the etiology of EBI and its potential as a target for future therapeutic intervention.
Authors:
Simge Yuksel; Yusuf Berk Tosun; Julian Cahill; Ihsan Solaroglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Turkish neurosurgery     Volume:  22     ISSN:  1019-5149     ISO Abbreviation:  Turk Neurosurg     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423821     Medline TA:  Turk Neurosurg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
Affiliation:
Koç University, Faculty of Medicine, Neuroscience Research Lab., Sariyer, Istanbul, Turkey.
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