| Early axial spondyloarthritis. | |
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MedLine Citation:
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PMID: 20592602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To summarize recent advances in the classification of preradiographic axial spondyloarthritis (SpA). RECENT FINDINGS: Inflammation in the sacroiliac joints precedes radiographic damage that is necessary to establish a diagnosis of ankylosing spondylitis (AS). Preradiographic axial SpA refers to patients with SpA who exhibit signs and symptoms of axial involvement, but lack criteria for AS. Patients with axial SpA can have remarkably similar clinical features and disease activity as those with early AS. MRI is a sensitive method for detecting sacroiliac joint inflammation, which is useful in predicting the development of AS. Whole-body MRI has emerged as a means to visualize additional areas of involvement. However, it may be less sensitive than conventional MRI, and thus its added value will need to be further assessed. The incorporation of MRI evaluation of the sacroiliac joints and HLA-B27 testing into criteria for identifying individuals with preradiographic axial disease has led to the development of criteria for classifying axial SpA. SUMMARY: The development of classification criteria for axial SpA will aid in the identification of patients suitable for clinical trials testing whether early intervention will slow the development and/or progression of structural changes in that lead to AS. |
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Authors:
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Robert A Colbert |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in rheumatology Volume: 22 ISSN: 1531-6963 ISO Abbreviation: Curr Opin Rheumatol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-04 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 9000851 Medline TA: Curr Opin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 603-7 Citation Subset: IM |
Affiliation:
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Pediatric Translational Research Branch, National Institute of Arthritis Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA. colbertr@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Disease Progression Early Diagnosis Humans Spondylitis, Ankylosing / classification*, radiography* |
| Grant Support | |
ID/Acronym/Agency:
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ZIA AR041184-01/AR/NIAMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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