Document Detail

Early atheroma in primary and secondary antiphospholipid syndrome: an intrinsic finding.
MedLine Citation:
PMID:  17977581     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The relationship between atherosclerosis and the antiphospholipid syndrome (APS) is unclear. This study compared intima-media thickness (IMT), arterial stiffness, and presence of plaques in APS patients and controls to evaluate the risk of atherosclerosis in this patient population. The study also explored the relationship between these parameters and cardiovascular risk factors. METHODS: Carotid and femoral IMT and stiffness were measured in 58 APS patients and 58 controls. In addition, antiphospholipid antibodies and cardiovascular risk factors were investigated and other systemic lupus erythematosus (SLE)-related serologic parameters were measured. Details of the patients' previous medical history and information regarding disease treatment were analyzed. RESULTS: A significant difference was found between IMT, arterial stiffness, and the presence of plaques in patients and controls (P<0.05). All of these parameters were independent of cardiovascular risk factors. No differences in these parameters were found between patients with primary APS and those with secondary APS, or between patients with thrombosis and those with obstetric manifestations. There was no correlation between SLE disease activity and atheroma. Patients with plaques had taken a lower total dose of corticosteroids and/or hydroxychloroquine. CONCLUSIONS: Some markers of early atherosclerosis could be detected in both primary and secondary APS, irrespective of clinical manifestations. These data suggest that atherosclerosis might be an intrinsic finding in APS patients, independent of cardiovascular risk factors, and that immunosuppressive treatment may prevent atherosclerosis.
Cristina C Belizna; Vincent Richard; Etienne Primard; Jean M Kerleau; Nicole Cailleux; Jean P Louvel; Isabelle Marie; Mohamed Hamidou; Christian Thuillez; Hervé Lévesque
Publication Detail:
Type:  Journal Article     Date:  2007-10-30
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  37     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-80     Citation Subset:  IM    
Department of Internal Medicine, Rouen University Hospital, Rouen, France.
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MeSH Terms
Antiphospholipid Syndrome / complications*
Atherosclerosis / complications*,  pathology
Carotid Arteries / pathology
Case-Control Studies
Femoral Artery / pathology
Middle Aged
Pregnancy Complications, Hematologic
Pulsatile Flow
Thromboembolism / complications*
Tunica Intima / pathology
Tunica Media / pathology

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