| Early assessment of outcome by ST-segment analysis after thrombolytic therapy in acute myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 7942474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
As an early marker of outcome, the sum of ST-segment elevation resolution between the electrocardiogram before and 3 hours after initiation of thrombolysis was investigated in 77 patients with acute myocardial infarction. Prospectively, three groups were defined according to complete (> or = 70%, n = 34), partial (< 70% to > or = 30%, n = 26), or no (< 30%, n = 17) ST resolution. There were considerable differences in the enzyme-determined infarct size (alpha-hydroxybutyrate dehydrogenase release for complete, partial, and no ST resolution: 529 +/- 397 IU/L, 689 +/- 484 IU/L, and 1293 +/- 742 IU/L, respectively; p = 0.0001) and the angiographic left ventricular function 1 week later (ejection fraction 58% +/- 10%, 53% +/- 13%, and 43% +/- 12%, respectively, p < 0.01; regional dyssynergic area 24 +/- 19, 39 +/- 23, and 50 +/- 21 U2, respectively, p < 0.01). Early reperfusion as assessed by creatine kinase release measured in 15-minute intervals was 90%, 65%, and 18%, respectively (p = 0.0001). Differences in degrees of ST-elevation resolution at 3 hours may help facilitate timely screening of patients for appropriate therapeutic intervention. Patients with complete ST resolution may be considered for early discharge, and patients with no ST resolution may be candidates for an early invasive approach or additional thrombolytic therapy. |
| | |
Authors:
|
R Dissmann; R Schröder; U Busse; M Appel; T Brüggemann; M Jereczek; T Linderer |
Related Documents
:
|
11249884 - Optimal time for predicting myocardial viability after successful primary angioplasty i... 8449084 - In-hospital prognostic relevance of a reduced ischemic threshold. studies in 357 consec... 3246264 - Continuous bed-side monitoring of the ecg for detection of silent myocardial ischaemia. 16630094 - Right ventricular infarction mimicking anterior infarction. 11032054 - Effects of ici 118.551, a selective beta-2 adrenergic blocking agent on the guinea pig ... 16221274 - Right heart failure due to loss of right ventricular capture in a patient with atrioven... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
|
Title: American heart journal Volume: 128 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1994 Nov |
Date Detail:
|
Created Date: 1994-11-18 Completed Date: 1994-11-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 851-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiopulmonary, Klinikum Steglitz, Free University Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Clinical Enzyme Tests Creatine Kinase / blood Electrocardiography* Female Fibrinolytic Agents / therapeutic use Heart Catheterization Humans Hydroxybutyrate Dehydrogenase / blood Male Middle Aged Myocardial Infarction / diagnosis, drug therapy*, epidemiology Prognosis Prospective Studies Thrombolytic Therapy* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Fibrinolytic Agents; EC 1.1.1.-/2-hydroxybutyrate dehydrogenase; EC 1.1.1.30/Hydroxybutyrate Dehydrogenase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: International experience with secundum atrial septal defect occlusion by the buttoned device.
Next Document: Coronary artery vasoconstriction after successful single angioplasty of the left anterior descending...