Document Detail


Early assessment of myocardial contractility by contrast-enhanced magnetic resonance (ceMRI) imaging after revascularization in acute myocardial infarction (AMI).
MedLine Citation:
PMID:  15683109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent studies have demonstrated that the size and shape of the hyperenhanced areas on contrast-enhanced magnetic resonance imaging (ceMRI) were nearly identical to areas of irreversible injury, as defined by histochemical staining. We compared the transmural extent of infarct (TEI), as defined by ceMRI, to the initial ECG findings for acute myocardial infarction (AMI), and we also assessed functional contractility according to TEI.
METHODS: 12 patients who presented with their first myocardial infarction underwent cine and ceMRI 4 weeks later after their successful revascularization. TEI and wall thickening were determined by using a 30-segment model.
RESULTS: Infarction was observed in 81 (23.9%) segments, of which 46 segments (56.8%) had abnormal wall motion and 35 segments (43.2%) had normal wall motion. Of the 35 segments, 33 (94.3%) had subendocardial infarction. 17 segments had infarct of less than 25% of the wall thickness, and all of them had normal wall motion. On the other hand, 11 segments had infarct of more than 75% of wall thickness, of which 11 (100%) had abnormal wall motion. None of segments with nearly transmural infarction were observed in non ST-elevation AMI. The majority of the segments with infarct had non-transmural infarction (87.5%), even if the segments were in ST-elevation AMI (76.1%). Infarct size, as defined by ceMRI, was strongly correlated with peak CK-MB and Troponin-T (r = 0.96, p < 0.001, r = 0.91, p < 0.001, respectively).
CONCLUSION: TEI defined by ceMRI is inversely related to the contractility after revascularization in AMI. We were able to predict the future contractile function of segments with infarction using ceMRI before revascularization.
Authors:
Hong Euy Lim; Hwan Seok Yong; Sung Hee Shin; Jeong Cheon Ahn; Hong Seog Seo; Dong Joo Oh; Young Moo Ro; Chang Gyu Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Korean journal of internal medicine     Volume:  19     ISSN:  1226-3303     ISO Abbreviation:  Korean J. Intern. Med.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-01     Completed Date:  2005-03-17     Revised Date:  2013-01-14    
Medline Journal Info:
Nlm Unique ID:  8712418     Medline TA:  Korean J Intern Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Contrast Media / administration & dosage
Female
Heterocyclic Compounds / administration & dosage
Humans
Magnetic Resonance Imaging, Cine / methods*
Male
Middle Aged
Myocardial Contraction*
Myocardial Infarction / pathology,  therapy*
Myocardial Revascularization*
Myocardium / pathology*
Necrosis
Organometallic Compounds / administration & dosage
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0199MV609F/gadoteridol

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