| Early appearance and mitotic activity of multinucleated giant cells in mice after combined injection of talc and prednisolone acetate. A model for studying rapid histiocytic polykarion formation in vivo. | |
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MedLine Citation:
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PMID: 628203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combined intraperitoneal injection of talc and particulate prednisolone acetate resulted in the formation of significant numbers of multinucleated giant cells within 48 hours. Neither one of these two agents had a comparable effect when injected alone. Evidence is presented showing that the multinucleated giant cells arose by cell fusion. Synchronous nuclear division could be observed in a considerable proportion of newly formed polykarions. Although the late prophases were usually normal, high proportions of abnormal mitotic figures were observed at later stages of mitosis, particularly in anaphase and telophase. The chromosome abnormalities were so severe that it is highly improbable that mitosis led to successful nuclear multiplication within a given syncytium. Similar to prednisolone acetate, prednisone elicited the formation of multinucleated giant cells when injected with talc. No polykarion formation was observed, however, when prednisolone acetate was substituted for other steroid preparations of similar particle size such as cortexon acetate, cortisone, or testosterone isobutyrate. |
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Authors:
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R Dreher; H U Keller; M W Hess; B Roos; H Cottier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Laboratory investigation; a journal of technical methods and pathology Volume: 38 ISSN: 0023-6837 ISO Abbreviation: Lab. Invest. Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-04-26 Completed Date: 1978-04-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376617 Medline TA: Lab Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Fusion Cell Nucleus / drug effects Cortisone / pharmacology Desoxycorticosterone / pharmacology Granuloma, Giant Cell / chemically induced, pathology* Histiocytes / pathology* Mice Mice, Inbred ICR Mitosis Prednisolone / pharmacology* Prednisone / pharmacology Talc / pharmacology* Testosterone / pharmacology |
| Chemical | |
Reg. No./Substance:
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14807-96-6/Talc; 50-24-8/Prednisolone; 53-03-2/Prednisone; 53-06-5/Cortisone; 58-22-0/Testosterone; 64-85-7/Desoxycorticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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