Document Detail

Early amino-acid administration improves preterm infant weight.
MedLine Citation:
PMID:  19444236     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Premature infants, especially those born less than 1500 g, often exhibit slow overall growth after birth and lack of early nutritional support may be an important element. We tested the hypothesis that early administration of amino acids (within the first few hours of life) to infants born at less than 1500 g would be associated with fewer infants that were less than the 10th percentile at 36 weeks post-conceptual age than infants that received amino acids after the first 24 h of life. STUDY DESIGN: A prospective intervention of early amino-acid (EAA) supplementation, began before 24 h of life, in preterm infants, <1500 g, was compared to a retrospective cohort of preterm infants receiving late amino-acid (LAA) supplementation, began after 24 h of life. The primary outcome variable was the proportion of infants at less than the 10th percentile at 36 weeks post-conceptual age. RESULT: Fewer infants fell below the 10th percentile (P<0.001) in the EAA group. Furthermore, infants in the EAA groups had significantly greater weight gains than did the LAA group (P<0.003) after adjusting for gestational age and time from birth to discharge. In addition, shorter duration of parenteral nutrition was associated with EAA supplementation (P<0.001). CONCLUSION: A prospective strategy of EAA in preterm infants <1500 g was associated with an improved weight gain, suggesting that nutrition that included amino acids may be critical during the first 24 h of life.
C J Valentine; S Fernandez; L K Rogers; P Gulati; J Hayes; P Lore; T Puthoff; M Dumm; A Jones; K Collins; J Curtiss; K Hutson; K Clark; S E Welty
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-08-17     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  428-32     Citation Subset:  IM    
Department of Pediatrics, Neonatal Nutrition Team, Nationwide Children's Hospital, Ohio State University, Columbus, OH 43205, USA.
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MeSH Terms
Amino Acids / administration & dosage*
Drug Administration Schedule
Infant, Low Birth Weight / growth & development*
Infant, Newborn
Infant, Premature / growth & development*
Intensive Care Units, Neonatal
Parenteral Nutrition / methods*
Prospective Studies
Weight Gain*
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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