| Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure. | |
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MedLine Citation:
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PMID: 20334525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess early changes in the lung after low-dose radiation exposure that may serve as targets for mitigation of lung injury in the aftermath of a terrorist event, we analyzed cytokine expression after irradiation. Adult mice were studied after whole-lung or total-body irradiation. Mouse pups of different ages were also investigated after total-body irradiation. mRNA abundance was analyzed in tissue and plasma, and pathological changes were assessed. In lung tissue, dose-related changes were seen in IL1B, IL1R2 and CXCR2 mRNA expression at 1 and 6 h after irradiation, concurrent with increases in plasma protein levels of KC/CXCL1 and IL6. However, in the pups, changes in IL1 abundance were not detected until 28 days of age, coincident with the end of postnatal lung growth, although apoptosis was detected at all ages. In conclusion, although cytokines were expressed after low doses of radiation, their role in the progression of tissue response is yet to be determined. They may be candidates for use in marker-based biodosimetry. However, the lack of cytokine induction in early life suggests that different end points (and mitigating treatments) may be required for children. |
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Authors:
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Carl J Johnston; Eric Hernady; Christina Reed; Sally W Thurston; Jacob N Finkelstein; Jacqueline P Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Radiation research Volume: 173 ISSN: 1938-5404 ISO Abbreviation: Radiat. Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-25 Completed Date: 2010-04-22 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 522-35 Citation Subset: IM; S |
Affiliation:
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Departments of Pediatrics and Neonatology, University of Rochester Medical Center, Rochester, New York 14642, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology,
radiation effects* Animals Cytokines / metabolism* Dose-Response Relationship, Radiation Female Gene Expression Regulation, Developmental / physiology*, radiation effects Lung / growth & development, metabolism*, radiation effects* Male Mice Mice, Inbred C57BL Radiation Dosage Whole-Body Irradiation* |
| Grant Support | |
ID/Acronym/Agency:
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5U19 AI06773-04/AI/NIAID NIH HHS; ES01247/ES/NIEHS NIH HHS; P30 ES001247/ES/NIEHS NIH HHS; P30 ES001247-230097/ES/NIEHS NIH HHS; P30 ES001247-240097/ES/NIEHS NIH HHS; P30 ES001247-24S10097/ES/NIEHS NIH HHS; P30 ES001247-250097/ES/NIEHS NIH HHS; P30 ES001247-25S10097/ES/NIEHS NIH HHS; P30 ES001247-319019/ES/NIEHS NIH HHS; P30 ES001247-329019/ES/NIEHS NIH HHS; P30 ES001247-339019/ES/NIEHS NIH HHS; P30 ES001247-349019/ES/NIEHS NIH HHS; P30 ES001247-359019/ES/NIEHS NIH HHS; U19 AI067733/AI/NIAID NIH HHS; U19 AI067733-040002/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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