| Early PET/CT after radiofrequency ablation in colorectal cancer liver metastases: is it useful? | |
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MedLine Citation:
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PMID: 20819630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Morphologic imaging after radiofrequency ablation (RFA) of liver metastases is hampered by an inflammatory response in the ablation margin, making the identification of local tumor progression (LTP) difficult. The aim of this study was to evaluate the efficacy of early (18)F-FDG PET/CT scanning to monitor the effectiveness of RFA in colorectal liver metastases. METHODS: Twelve patients with 20 metastases were treated with RFA for colorectal liver metastases. They underwent PET/CT within 2 weeks before RFA and within 24 hours after RFA (so termed "early PET/CT"). PET/CT was repeated at 1, 3, and 6 months, and then every 6 months after ablation. The standard of reference was based on available clinical and radiological follow-up data. RESULTS: Early PET/CT revealed total photopenia in 16 RFA-treated metastases, which were found to be without residual tumor on the final PET/CT scan. Three RFA-treated metastases with focal uptake were identified as local tumor progression, which necessitated further treatment. One RFA-treated metastasis with rim-shaped uptake was regarded as inflammation. The results of the early PET/CT scanning were consistent with the findings of the final follow-up. CONCLUSIONS: PET/CT performed within 24 hours after RFA can effectively detect whether residual tumor exists for colorectal cancer liver metastases. The results can guide further treatment, and may improve the efficacy of RFA. |
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Authors:
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Zhao-Yu Liu; Zhi-Hui Chang; Zai-Ming Lu; Qi-Yong Guo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 123 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-09-07 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 1690-4 Citation Subset: IM |
Affiliation:
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Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China. liuzy@sj-hospital.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Catheter Ablation* Colorectal Neoplasms / complications*, radiography, radionuclide imaging, therapy* Female Fluorodeoxyglucose F18 / therapeutic use Humans Liver Neoplasms / radiography, radionuclide imaging, secondary*, therapy* Male Middle Aged Positron-Emission Tomography / methods* Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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