Document Detail

Early aerobic training increases end-tidal CO2 pressure during exercise in patients after acute myocardial infarction.
MedLine Citation:
PMID:  15277738     Owner:  NLM     Status:  MEDLINE    
End-tidal CO2 partial pressure (PETCO2) has been suggested as a noninvasive index reflecting cardiac output under constant ventilation. The aim of this study was to examine whether PETCO2 does reflect cardiac output, even during exercise, in patients with acute myocardial infarction (AMI) undergoing exercise training early after onset. Method and Results Patients aged 47-73 years were randomly assigned to either a training group (n=18) or a control group (n=18) 1 week after the onset of AMI. Those in the training group performed exercise training under supervision at the anaerobic threshold level for 2 weeks, while patients in the control group followed a conventional walking regimen. In the training group, but not in the control group, PETCO2 at the respiratory compensation point increased significantly from 39.1+/-3.5 to 41.1+/-3.7 mmHg (p<0.01). Similarly, the cardiac index at peak exercise increased only in the training group (from 6.04+/-0.98 to 7.31+/-0.97 L/min per m2, p<0.01). These 2 measurements correlated well both before and after the study period. Peak oxygen uptake and anaerobic threshold were increased only in the training group. Conclusions Aerobic exercise training early after the onset of AMI significantly increased PETCO2 during exercise, which may reflect an improvement in cardiac output during exercise in response to physical training via a decreased ventilation-perfusion mismatch.
Yoko Eto; Akira Koike; Akihiro Matsumoto; Shin-Ichi Momomura; Akihiko Tajima; Tadanori Aizawa; Long-Tai Fu; Haruki Itoh
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2005-04-12     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  778-83     Citation Subset:  IM    
The Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Japan.
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MeSH Terms
Carbon Dioxide / blood*
Exercise / physiology*
Middle Aged
Myocardial Infarction / physiopathology,  rehabilitation*
Oxygen / blood
Partial Pressure
Physical Endurance*
Regression Analysis
Tidal Volume / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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