| Early adrenocortical recovery after glucocorticoid therapy in children with leukemia. | |
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MedLine Citation:
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PMID: 15181060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The duration of glucocorticoid-induced inhibition that occurs in the hypothalamic-pituitary-adrenal (HPA) axis after discontinuation of treatment is controversial. The main objective of this prospective study was to evaluate the inhibition of the HPA axis by dexamethasone in children and adolescents with acute lymphoid leukemia. Thirty-five patients (median age of 6.9 yr) were evaluated. A stimulus test with ovine CRH (1 microg/kg) was performed before the introduction of dexamethasone (6 mg/m2.d for 28 d), in the 8th and 28th days of glucocorticoid therapy, and 48 h and 1 month after discontinuation of glucocorticoid therapy. Suppression of the basal secretion as well as the maximum concentration of ACTH occurred during glucocorticoid therapy (P < 0.01). The pituitary function before the introduction of dexamethasone was similar to the one seen 48 h and 1 month after withdrawing it. Suppression of the adrenal function was detected during glucocorticoid therapy, which persisted for 48 h after the steroid was removed from treatment (P < 0.01). One month after ceasing the administration of the glucocorticoid, the adrenal function was similar to that before glucocorticoid therapy. According to these results, a clinical and laboratory follow-up of the HPA axis in the month after the cessation of dexamethasone therapy is suggested to determine glucocorticoid replacement. |
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Authors:
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Cristiane de Freitas Cunha; Ivani Novato Silva; Francisca Lee Finch |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 89 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-07 Completed Date: 2004-07-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2797-802 Citation Subset: AIM; IM |
Affiliation:
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Dvision of Pediatric Endocrinology, University Hospital, Federal University of Minas Gerais, 30130-100 Belo Horizonte, Minas Gerais, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex
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drug effects*,
physiology* Adrenocorticotropic Hormone / blood Biological Markers Child Dexamethasone / administration & dosage, adverse effects* Glucocorticoids / administration & dosage, adverse effects* Humans Hydrocortisone / blood Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Glucocorticoids; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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