Document Detail


Early acute phase response following total hip replacement.
MedLine Citation:
PMID:  19828914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The acute phase proteins are commonly known universal markers of the inflammatory process. The aim of the study was the evaluation of the acute phase response in the first 6 months THR. The secondary aim was to check if the type of hip replacement affects the acute phase response. MATERIAL AND METHODS: The study group consisted of 40 patients who underwent THA using uncemented (20) and cemented (20) endoprostheses. The concentrations of C-reactive protein, alpha-glycoprotein, and alpha-1-antichymotripsin, and microheterogeneity of AGP were evaluated. RESULTS: The blood levels of the acute phase proteins CRP, AGP, ACT rose significantly at 2 and 14 days after the surgery to return to preoperative values at 6 months after the surgery. The V3 variant of microheterogeneity of AGP, absent under normal conditions, and representative of acute inflammation, was found in a few patients preoperatively. In postoperative evaluations, it was found in the vast majority of the patients. CONCLUSIONS: The analysis of the profiles of the glycosylation of AGP shows that the presence of the acute inflammatory response immediately following total hip replacement, which later changes into persistent chronic inflammation, is more pronounced in patients receiving cemented endoprosthesis.
Authors:
Jacek Markuszewski; Ma??gorzata Wierusz-Koz??owska; Waldemar Wo??niak; Kinga Le??niewska; Magdalena Sobieska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ortopedia, traumatologia, rehabilitacja     Volume:  11     ISSN:  1509-3492     ISO Abbreviation:  -     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-10-15     Completed Date:  2010-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240146     Medline TA:  Ortop Traumatol Rehabil     Country:  Poland    
Other Details:
Languages:  eng; pol     Pagination:  324-32     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Orthopaedics and Traumatology, Karol Marcinkowski University of Medical Sciences, Pozna??, Poland. jmarkuszewski@orsk.ump.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Acute-Phase Proteins / analysis*
Acute-Phase Reaction / etiology*
Adult
Aged
Analysis of Variance
C-Reactive Protein / analysis
Female
Glycoproteins / blood
Hip Prosthesis / adverse effects*
Humans
Male
Middle Aged
Osteoarthritis, Hip / immunology,  surgery
Poland
Transferrin / analysis
alpha 1-Antichymotrypsin / blood
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Glycoproteins; 0/alpha 1-Antichymotrypsin; 11096-37-0/Transferrin; 9007-41-4/C-Reactive Protein

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