| Early acquisition of herpes simplex virus type 1 antibodies in children--a longitudinal serological study. | |
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MedLine Citation:
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PMID: 17644470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Herpes simplex virus type 1 (HSV-1) infections are commonly acquired in childhood, asymptomatically or as a symptomatic infection. However, little is known about the time of HSV seroconversion during infancy and early childhood. OBJECTIVE: To investigate the acquisition of IgG-antibodies to HSV in infants and children. STUDY DESIGN: A longitudinal study, using type-specific HSV-1 and herpes simplex virus type 2 (HSV-2) enzyme-linked immunosorbent assays on sera collected from the mother and from their child at the age of 3, 5, 6, 12, 13 and 30 months. RESULTS: The maternal seroprevalences for HSV-1 was 65% and for HSV-2 19%. A gradual loss of maternal antibodies was seen, with few infants having detectable HSV-1 antibodies at the age of 1 year. A more rapid decline was registered for HSV-2 antibodies. A small number of new HSV-1 infections occurred in 3-5-month olds and more than half of the new infections were detected before the age of 13 months. At the age of 30 months, 30% of the children were HSV-1 antibody positive. CONCLUSION: Seroconversion to HSV-1 commonly occurs already during infancy, suggesting that HSV-1 is transmitted primarily from parent to child. |
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Authors:
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Petra Tunbäck; Tomas Bergström; Bo A Claesson; Rose-Marie Carlsson; Gun-Britt Löwhagen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-20 |
Journal Detail:
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Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Volume: 40 ISSN: 1386-6532 ISO Abbreviation: J. Clin. Virol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-31 Completed Date: 2007-12-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9815671 Medline TA: J Clin Virol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 26-30 Citation Subset: IM |
Affiliation:
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Department of Dermatology and Venereology, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. petra.tunback@derm.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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blood* Child, Preschool Female Herpes Simplex / epidemiology*, transmission Herpesvirus 1, Human / immunology* Herpesvirus 2, Human / immunology* Humans Infant Infectious Disease Transmission, Vertical Longitudinal Studies Male Pregnancy Pregnancy Complications, Infectious Seroepidemiologic Studies |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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