| Early abciximab use in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention improves long-term outcome. Data from EUROTRANSFER Registry. | |
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MedLine Citation:
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PMID: 20491016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Primary percutaneous coronary intervention (PCI) is the preferred method of reperfusion in patients with ST elevation myocardial infarction (STEMI). Abciximab is a well established adjunct to primary PCI. The proper timing of abciximab administration in STEMI patients has been investigated in randomised trials, registries and metanalysis, providing conflicting results. METHODS: Consecutive data on STEMI patients, transferred for primary PCI in hospital/ambulance STEMI networks between November 2005 and January 2007, from 15 PCI centres in seven European countries was gathered together for a one-year long-term clinical observation (93% rate of completeness). RESULTS: Data from 1,650 patients was collected in the EUROTRANSFER Registry. Abciximab was administered to 1,086 patients (66%), 727 patients received early (at least 30 minutes prior to first balloon inflation) abciximab (EA), and another 359 patients received late abciximab (LA). One year mortality was 5.8% in the EA group vs 10.3% with LA (p = 0.007). Adjustment for propensity score methods for EA administration did not change the results, still providing a favourable outcome for the EA group (p = 0.004). It was also revealed that only a minority of patients (36%) were treated within the 90-minute recommended time window from first medical contact to PCI (and 60% for the 120-min time delay). CONCLUSIONS: Patients transferred for primary PCI in STEMI hospital networks showed lower rates of death in long-term one-year clinical follow-up when treatment with abciximab was started early. |
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Authors:
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Zbigniew Siudak; Tomasz Rakowski; Artur Dziewierz; Magnus Janzon; Ralf Birkemeyer; Justyna Stefaniak; Łukasz Partyka; Krzysztof Zmudka; Dariusz Dudek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kardiologia polska Volume: 68 ISSN: 0022-9032 ISO Abbreviation: Kardiol Pol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376352 Medline TA: Kardiol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 539-43 Citation Subset: IM |
Affiliation:
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Institute of Cardiology, Collegium Medicum, Jagiellonian University, Krakow, Poland. zbigniew.siudak@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary* Antibodies, Monoclonal / administration & dosage* Combined Modality Therapy Drug Administration Schedule Electrocardiography Europe / epidemiology Female Follow-Up Studies Humans Immunoglobulin Fab Fragments / administration & dosage* Male Middle Aged Myocardial Infarction / diagnosis, mortality, therapy* Platelet Aggregation Inhibitors / administration & dosage* Registries / statistics & numerical data* Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Platelet Aggregation Inhibitors; 143653-53-6/abciximab |
| Comments/Corrections | |
Comment In:
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Kardiol Pol. 2010 May;68(5):544-5
[PMID:
20491017
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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