Document Detail

Early versus delayed minimal enteral feeding and risk for necrotizing enterocolitis in preterm growth-restricted infants with abnormal antenatal Doppler results.
MedLine Citation:
PMID:  20013579     Owner:  NLM     Status:  MEDLINE    
We studied the effect of early (< or = 5 days) versus delayed (> or = 6 days) initiation of minimal enteral feeding (MEF) on the incidence of necrotizing enterocolitis (NEC) and feeding intolerance in preterm infants with intrauterine growth restriction (IUGR) and abnormal antenatal Doppler results. We performed a randomized, nonblinded pilot trial of infants receiving early or delayed MEF in addition to parenteral feeding within 48 hours of life. Demographic data, maternal preeclampsia, antenatal steroid exposure, Doppler studies, as well as cases of NEC and feeding intolerance were all recorded. Of the 84 infants enrolled, 81 completed the study: 40 received early (median age: 2 days, range: 1 to 5 days) and 41 delayed (median age: 7 days, range: 6 to 14 days) MEF. The incidence of NEC and feeding intolerance was not significantly different between groups (p = 0.353 and p = 0.533, respectively). Birth weight was an independent risk factor for NEC in both groups. Early MEF of preterm infants with IUGR and abnormal antenatal Doppler results may not have a significant effect on the incidence of NEC or feeding intolerance. Furthermore, birth weight seems to be an independent risk factor for the development of NEC, irrespectively of the timing of MEF introduction.
Paraskevi Karagianni; Despina D Briana; George Mitsiakos; Anestis Elias; Theodoros Theodoridis; Elias Chatziioannidis; Maria Kyriakidou; Nikolaos Nikolaidis
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-12-10
Journal Detail:
Title:  American journal of perinatology     Volume:  27     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-73     Citation Subset:  IM    
Copyright Information:
Copyright Thieme Medical Publishers.
2nd NICU and Neonatology Department, Aristotle University of Thessaloniki, G.P.N. Papageorgiou, Thessaloniki, Greece.
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MeSH Terms
Enteral Nutrition / adverse effects*
Enterocolitis, Necrotizing / epidemiology*,  etiology*,  ultrasonography
Fetal Growth Retardation / ultrasonography*
Infant, Newborn
Infant, Premature*
Pilot Projects
Risk Factors
Time Factors
Ultrasonography, Doppler
Ultrasonography, Prenatal*

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