| Early Treatment of a Progressive Rasmussen's Like Syndrome with Ganciclovir. | |
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MedLine Citation:
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PMID: 21320836 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Escalating focal sensorimotor seizures, progressive neurologic deficit and cognitive decline with associated typical magnetic resonance imaging (MRI) findings or pathological confirmation constitute the syndrome of Rasmussen's encephalitis. Methods: Three patients with this clinical scenario had long-term follow-up after being given the antiviral drug ganciclovir 10 mg/kg/day IV for ten days within one to three months of disease onset. Results: Seizures occurred at least hourly and were localized to the Rolandic region. The MRIs were normal in one patient and in two showed changes consistent with ongoing seizures. Two patients, one whose short-term outcome was reported previously, had immediate and sustained cessation of seizures and resolution of their neurologic deficit. One patient with seizures from both hemispheres did not respond and went on to hemispherectomy that confirmed chronic encephalitis. Seizures continued in five other patients treated 6 to 72 months after disease onset. Conclusion: The sustained seizure control after ganciclovir in two of three patients suggests this drug may be effective when given early in the course of this subacute intractable focal epilepsy syndrome. |
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Authors:
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Richard S McLachlan; David Diosy; Simon Levin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 38 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 296-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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