Document Detail

Early transtympanic steroid injection in patients with 'poor prognosis' idiopathic sensorineural sudden hearing loss.
MedLine Citation:
PMID:  21124045     Owner:  NLM     Status:  In-Data-Review    
Objective: The present trial is aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with 'poor prognosis' idiopathic sensorineural sudden hearing loss (ISSHL). Methods: Seventy-six patients, diagnosed as having ISSHL with 'poor prognosis', were randomized into a transtympanic group and a control group. Thirty-nine patients received conventional steroid treatment and 37 patients received 4 courses of additional transtympanic injections of methylprednisolone 7 days after conventional steroid treatment. Results: In the transtympanic group 45.9% of the patients had at least 15 dB improvement in pure tone average compared with 20.5% of the patients in the control group at the 8-week follow-up audiogram. In the transtympanic group 43.2% of the patients had an improvement of ≥15% in speech discrimination, compared with 17.9% of the patients in the control group 8 weeks after the treatment. The differences between the 2 groups were statistically significantly. Conclusion: The outcome was better for the patients with 'poor prognosis' ISSHL if the transtympanic steroid therapy could be applied early.
Yide Zhou; Hongliang Zheng; Qing Zhang; Peter A Campione
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Publication Detail:
Type:  Journal Article     Date:  2010-12-03
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  73     ISSN:  1423-0275     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Department of Otolaryngology, Head and Neck Surgery, Changhai Hospital, Shanghai, China.
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