Document Detail

Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction.
MedLine Citation:
PMID:  20670848     Owner:  NLM     Status:  In-Process    
BACKGROUND: Vagal nerve stimulation (VS) has been suggested to be an effective adjunct to reperfusion therapy in myocardial infarction (MI). However, the effect of VS on left ventricular (LV) remodeling after reperfused MI has not been examined.
METHODS AND RESULTS: We investigated the effects of early, brief VS on acute inflammatory reactions (study 1) and chronic LV remodeling (study 2) in a rabbit model of reperfused MI. In study 1, rabbits were subjected to 60-minute coronary artery occlusion followed by reperfusion alone (MI, n = 8) or treated with 24-hour VS (MI-VS, n = 8). At 24 hours after ischemia-reperfusion, MI-VS rabbits showed significantly decreased myocardial infiltration of neutrophils and reduced myocardial expressions of tumor necrosis factor-alpha and matrix metalloproteinase-8 and -9, compared with MI rabbits. Myocardial expression of interleukin-6 was not affected by VS. In study 2, rabbits were subjected to coronary occlusion and reperfusion alone (n = 16) or treated with VS for 3 days (n = 14). At 8 weeks after ischemia-reperfusion, MI-VS rabbits showed significantly improved LV dysfunction and dilatation, and significantly reduced infarct size, infarct wall thinning, and LV weight compared with MI rabbits.
CONCLUSION: Early, short-term VS attenuates LV remodeling after reperfused MI, which may be associated with suppression of acute inflammatory reactions.
Kazunori Uemura; Can Zheng; Meihua Li; Toru Kawada; Masaru Sugimachi
Related Documents :
3746148 - Non-invasive detection of coronary artery disease by body surface electrocardiographic ...
2766758 - Effect of flosequinan in patients with acute-onset heart failure complicating acute myo...
21031128 - Genetic causes of myocardial infarction: new insights from genome-wide association stud...
18837278 - Exploring the meaning of recovery following myocardial infarction.
15472638 - Postischemic stunning after adenosine vasodilator stress.
12062338 - Atrial structure and fibres: morphologic bases of atrial conduction.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-08
Journal Detail:
Title:  Journal of cardiac failure     Volume:  16     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-99     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Beneficial effects of atorvastatin on lung structural remodeling and function in ischemic heart fail...
Next Document:  Spatial heterogeneity of protein expression induced by dyssynchronous right ventricular pacing in th...