Document Detail


Early sensitivity training for parents of preterm infants: impact on the developing brain.
MedLine Citation:
PMID:  19952869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After birth, preterm infants face a stressful environment, which may negatively impact early brain development and subsequent neurobehavioral outcomes. This randomized controlled trial involving 45 women with infants <30-wk gestation, assessed the effectiveness of training parents in reducing stressful experiences. Intervention consisted of 10 sessions in the Neonatal Intensive Care Unit (NICU). Postintervention, at term-equivalent (40-wk postmenstrual age), magnetic resonance imaging (MRI) was performed to evaluate brain structure and development. Quantitative volumetric techniques were used to estimate overall and regional brain volumes for different tissue types including CSF, CGM, DNGM, UWM, and MWM. DTI was used to evaluate the integrity and maturation of white matter by ADC and FA. Maturation and connectivity of white matter, characterized by diffusion MR measures of ADC and FA, were significantly enhanced in the intervention group, who displayed greater restriction in ADC and increase in FA. There were no significant effects on either brain volumes or on short-term medical outcomes. Thus, sensitivity training for parents in the NICU is associated with improved cerebral white matter micro-structural development in preterm infants.
Authors:
Jeannette Milgrom; Carol Newnham; Peter J Anderson; Lex W Doyle; Alan W Gemmill; Katherine Lee; Rod W Hunt; Merilyn Bear; Terrie Inder
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  330-5     Citation Subset:  IM    
Affiliation:
Department of Clinical & Health Psychology, Austin Health, Victoria, Australia. jeannette.milgrom@austin.org.au
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00883974
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological
Adult
Australia
Brain / growth & development*,  pathology,  physiopathology
Child Psychology*
Diffusion Magnetic Resonance Imaging
Female
Gestational Age
Humans
Infant Behavior*
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Intensive Care, Neonatal / methods*
Male
Maternal Behavior*
Mother-Child Relations*
Stress, Psychological / etiology,  pathology,  physiopathology,  prevention & control*
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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