| Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise training. | |
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MedLine Citation:
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PMID: 21543642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inferior lead early repolarization pattern (ERP) recently has been associated with sudden cardiac death. Although ERP is common among athletes, prevalence, ECG lead distribution, clinical characteristics, and effects of physical training remain uncertain. We sought to examine the nonanterior ERP in competitive athletes. METHODS AND RESULTS: ERP was assessed in a cross-sectional cohort of collegiate athletes (n = 879). The relationship between ERP and cardiac structure were then examined in a longitudinal subgroup (n = 146) before and after a 90-day period of exercise training. ERP was defined as J-point elevation ≥ 0.1 mV in at least 2 leads within a nonanterior territory (inferior [II, III, aVF] or lateral territory [I, aVL, V4-V6]). Nonanterior ERP was present in 25.1% (221/879) of athletes, including the inferior subtype in 3.8% (33/879). Exercise training led to significant increases in the prevalence of ERP and the inferior subtype, but there were no associations between ERP and echocardiographic measures of left ventricular remodeling. In a multivariable model, ERP was associated with black race (odds ratio [OR], 5.84; 95% CI, 3.54 to 9.61; P < 0.001), increased QRS voltage (OR, 2.08; 95% CI, 1.71 to 2.52; P < 0.001), and slower heart rate (OR, 1.54; 95% CI, 1.26 to 1.87; P < 0.001). CONCLUSIONS: Nonanterior ERP, including the inferior subtype, is common and has strong clinical associations among competitive athletes. The finding of increased ERP prevalence after intense physical training establishes a strong association between exercise and ERP. |
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Authors:
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Peter A Noseworthy; Rory Weiner; Jonathan Kim; Varsha Keelara; Francis Wang; Brant Berkstresser; Malissa J Wood; Thomas J Wang; Michael H Picard; Adolph M Hutter; Christopher Newton-Cheh; Aaron L Baggish |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-04 |
Journal Detail:
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Title: Circulation. Arrhythmia and electrophysiology Volume: 4 ISSN: 1941-3084 ISO Abbreviation: Circ Arrhythm Electrophysiol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-17 Completed Date: 2011-10-13 Revised Date: 2012-06-26 |
Medline Journal Info:
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Nlm Unique ID: 101474365 Medline TA: Circ Arrhythm Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 432-40 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arrhythmias, Cardiac / physiopathology* Athletes* Cross-Sectional Studies Death, Sudden, Cardiac / epidemiology Electrocardiography* Exercise / physiology* Female Humans Longitudinal Studies Male Multivariate Analysis Prevalence Prospective Studies Risk Factors Ventricular Remodeling / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL080025/HL/NHLBI NIH HHS; K23 HL080025/HL/NHLBI NIH HHS; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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