Document Detail

Early pregnancy maternal serum PAPP-A and urinary protein-creatinine ratio as predictive markers of pregnancy induced hypertension.
MedLine Citation:
PMID:  20395925     Owner:  NLM     Status:  MEDLINE    
Pregnancy induced hypertension (PIH) is a major complication of pregnancy and is associated with high maternal and perinatal morbidity and mortality. The aim of this study was to investigate the possible causal association of PIH with maternal serum PAPP-A and urinary protein-creatinine ratio (UPCr) as well as to evaluate the usefulness of these two variables as predictive markers of PIH. A total 200 women of 8-16 weeks of pregnancy were enrolled in this study. All the patients were followed up till delivery for the development of pregnancy induced hypertension. Thirty patients were lost in the follow up, 3(1.76%) developed preeclampsia (PE) and 14(8.23%) gestational hypertension (GH). By a nested case-control design the 17 pregnancy induced hypertension cases were compared with 48 Controls with normal pregnancy outcome. Maternal serum PAPP-A was significantly lower in the pregnancy induced hypertension group compared to Control [mIU/ml, median (range) 1.8(0.70-4.1) vs. 5.45(2.7-10), p<0.001]. UPCr was significantly higher in the pregnancy induced hypertension group compared to Control (mg/mmol, mean+/-SD, 6.86+/-1.56 vs. 4.75+/-0.96, p<0.001). When tested as a predictive marker of pregnancy induced hypertension the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of maternal serum PAPP-A in the lowest 25th percentile were 82%, 95%, 87% and 93%. At 75th percentile the sensitivity, specificity, PPV and NPV of UPCr were 52%, 85%, 56% and 83% respectively.
B Nasrin; N Fatema; F Jebunnessa; S Shamim; S B Chowdhury; L Ali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mymensingh medical journal : MMJ     Volume:  19     ISSN:  1022-4742     ISO Abbreviation:  Mymensingh Med J     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9601799     Medline TA:  Mymensingh Med J     Country:  Bangladesh    
Other Details:
Languages:  eng     Pagination:  267-74     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, and Square Hospital, Dhaka, Bangladesh.
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MeSH Terms
Biological Markers / blood,  urine
Creatinine / urine*
Lipids / blood
Pre-Eclampsia / blood*,  epidemiology,  urine*
Predictive Value of Tests
Pregnancy Outcome
Pregnancy Proteins / urine*
Pregnancy-Associated Plasma Protein-A / metabolism*
Prospective Studies
Sensitivity and Specificity
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 0/Pregnancy Proteins; 60-27-5/Creatinine; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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