| Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. | |
| | |
MedLine Citation:
|
PMID: 20810515 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To identify early predictors of sacroiliac (SI) involvement in a cohort of patients with enthesitis-related arthritis (ERA). METHODS: During a 7-year followup period, all consecutive patients fulfilling the ILAR classification criteria for ERA were enrolled. Data collected included demographic, clinical and laboratory variables at disease onset, at the onset of inflammatory back pain, and at the last available followup visit. Pelvis radiographs and dynamic magnetic resonance imaging (MRI) scans for SI joints were obtained simultaneously in all patients who developed inflammatory back pain. RESULTS: Fifty-nine children with ERA were studied; 40 male, 19 female; median age at disease onset 9 years 4 months (range 6 yrs 6 mo - 13 yrs 3 mo). At a median interval after disease onset of 1 year 3 months, 21 children reported symptoms of inflammatory back pain. In all cases, radiographs of SI joints were negative, while dynamic MRI revealed acute sacroiliitis in 17 cases. Multivariate analysis showed that the early predictors of SI were the number of active joints (p < 0.03) and the number of active entheses (p < 0.001) at onset. CONCLUSION: In our cohort, roughly 30% of children with ERA/juvenile idiopathic arthritis develop clinical and MRI evidence of sacroiliitis, detectable with dynamic MRI as early as 1 year after disease onset. Additional data from larger case series are needed to assess the specificity and sensitivity of this technique in the early phase of the disease and to confirm the rate of SI involvement reported in this cohort. |
| | |
Authors:
|
Ilaria Pagnini; Sara Savelli; Marco Matucci-Cerinic; Claudio Fonda; Rolando Cimaz; Gabriele Simonini |
Related Documents
:
|
15251085 - Magnetic resonance imaging of psoriatic arthritis: insight from traditional and three-d... 19477615 - Mri quantification of rheumatoid arthritis: current knowledge and future perspectives. 15599345 - Comparison of the clinical outcomes of patients having sounds in the temporomandibular ... 22451545 - Intraindividual comparison of gadobutrol and gadopentetate dimeglumine for detection of... 18581345 - Vascular space occupancy-dependent functional mri by tissue suppression. 15069405 - Graves' ophthalmopathy evolution studied by mri during childhood and adolescence. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-01 |
Journal Detail:
|
Title: The Journal of rheumatology Volume: 37 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
|
Languages: eng Pagination: 2395-401 Citation Subset: IM |
Affiliation:
|
Department of Paediatric Rheumatology, University of Florence, Anna Meyer Children's Hospital, Viale Pieraccini 24, 50139 Florence, Italy. dott.pagnini@alice.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased production of a proliferation-inducing ligand (APRIL) by peripheral blood mononuclear cell...
Next Document: Comparative study of mitoxantrone efficacy profile in patients with relapsing--remitting and seconda...