Document Detail


Early predictors of hypertension in prematurely born adolescents.
MedLine Citation:
PMID:  20586997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE:  To assess the blood pressure of former preterm and term matched adolescent controls and to identify risk factors associated with blood pressure at 16 years.
DESIGN:   Observational cohort study. Secondary analysis of a randomized clinical trial.
SETTING: Three academic centres participating in the Multicenter Indomethacin IVH Prevention Trial.
PARTICIPANTS:   A total of 296 children born in 1989-1992 with birth weights 600 to <1250 g who participated in the Multicenter Indomethacin IVH Prevention Trial and 95 term controls were evaluated at 16 years.
MAIN OUTCOME MEASURES:   Blood pressure and predictors of blood pressure.
RESULTS:   The adjusted mean difference in blood pressure for preterm adolescents was 5.1 mm Hg; p=0.002 for systolic and 2.1 mm Hg; p=0.027 for diastolic blood pressure. Among preterms, the primary predictors of increased systolic blood pressure were weight gain velocity between birth and 36 months (b=8.54, p<0.001), pre-eclampsia (b=5.67, p=0.020), non-white race (b=3.77, p=0.04) and male gender (b=5.09). Predictors of diastolic blood pressure were weight gain velocity between birth and 36 months (b=4.69, p=0.001), brain injury (b=6.51, p=0.002) and male gender (b=-2.4, p=0.02).
CONCLUSIONS:   Early programming secondary to increased early weight gain velocity, intrauterine stress and neonatal brain injury may all contribute to risk of increased blood pressure among former preterm adolescents.
Authors:
Betty R Vohr; Walter Allan; Karol H Katz; Karen C Schneider; Laura R Ment
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2011-01-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1812-8     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica.
Affiliation:
.Department of Pediatrics, Women and Infants' Hospital, Providence, RI, USA. bvohr@wihri.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain Injuries / epidemiology
Case-Control Studies
Cohort Studies
Female
Humans
Hypertension / epidemiology*
Infant, Extremely Low Birth Weight / physiology*
Infant, Newborn
Infant, Premature / physiology*
Male
Prehypertension / epidemiology*
Risk Factors
Weight Gain / physiology
Grant Support
ID/Acronym/Agency:
NS 27116-20/NS/NINDS NIH HHS; R01 NS027116-20/NS/NINDS NIH HHS
Comments/Corrections

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