| Early predictors of hypertension in prematurely born adolescents. | |
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MedLine Citation:
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PMID: 20586997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the blood pressure of former preterm and term matched adolescent controls and to identify risk factors associated with blood pressure at 16 years. DESIGN: Observational cohort study. Secondary analysis of a randomized clinical trial. SETTING: Three academic centres participating in the Multicenter Indomethacin IVH Prevention Trial. PARTICIPANTS: A total of 296 children born in 1989-1992 with birth weights 600 to <1250 g who participated in the Multicenter Indomethacin IVH Prevention Trial and 95 term controls were evaluated at 16 years. MAIN OUTCOME MEASURES: Blood pressure and predictors of blood pressure. RESULTS: The adjusted mean difference in blood pressure for preterm adolescents was 5.1 mm Hg; p=0.002 for systolic and 2.1 mm Hg; p=0.027 for diastolic blood pressure. Among preterms, the primary predictors of increased systolic blood pressure were weight gain velocity between birth and 36 months (b=8.54, p<0.001), pre-eclampsia (b=5.67, p=0.020), non-white race (b=3.77, p=0.04) and male gender (b=5.09). Predictors of diastolic blood pressure were weight gain velocity between birth and 36 months (b=4.69, p=0.001), brain injury (b=6.51, p=0.002) and male gender (b=-2.4, p=0.02). CONCLUSIONS: Early programming secondary to increased early weight gain velocity, intrauterine stress and neonatal brain injury may all contribute to risk of increased blood pressure among former preterm adolescents. |
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Authors:
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Betty R Vohr; Walter Allan; Karol H Katz; Karen C Schneider; Laura R Ment |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2011-01-20 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1812-8 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica. |
Affiliation:
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.Department of Pediatrics, Women and Infants' Hospital, Providence, RI, USA. bvohr@wihri.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain Injuries / epidemiology Case-Control Studies Cohort Studies Female Humans Hypertension / epidemiology* Infant, Extremely Low Birth Weight / physiology* Infant, Newborn Infant, Premature / physiology* Male Prehypertension / epidemiology* Risk Factors Weight Gain / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS 27116-20/NS/NINDS NIH HHS; R01 NS027116-20/NS/NINDS NIH HHS |
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