Document Detail


Early-Onset Infections of Very-Low-Birth-Weight Infants in Polish Neonatal Intensive Care Units.
MedLine Citation:
PMID:  22466319     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: The objective of this study was to investigate the incidence, causes, the risk factors, etiologic agents and the outcomes of early-onset infections (EOIs) in very-low-birth-weight newborns in Polish Neonatal Intensive Care Units (NICU) METHODS: Continuous prospective infection surveillance conducted during 2009 at six Polish NICUs and included 910 newborns whose birth weight was lower than 1500 grams. Infections were defined according to the Gastmeier's criteria. EOIs were diagnosed <3 days after delivery. RESULTS: The frequency of early-onset septicemia (EOS) was 7.0% and of early-onset pneumonia (EO-pneumonia): 8.6%. The factors significantly increasing the risk of EOS were low gestational age (GA), small birth weight, low score in the CRIB and Apgar score as well as maternal chorioamnionitis. The perinatal prophylaxis did not have an influence on the occurrence of EO-S. The factors considerably increasing the risk of EO-Pneumonia were: low scores in the CRIB and Apgar scores, a low GA and bacterial vaginosis in the child's mother during pregnancy. The most important etiologic organisms were Gram-positive cocci (39.7% of all the infections, 47.8% in EOS), Streptococcus agalactiae (20% of the EOS), Gram-negative bacilli (33.3% isolates), yeast-like fungi (isolated in 7.9% of cases) and atypical bacteria (22% of the cases of EO-Pneumonia). CONCLUSIONS: The observed frequency of EOS did not differ from the one described in the literature, whereas the frequency of EO-pneumonia was higher. The bacterial etiologies suggest the vertical transmission of the pathogens and a close relationship between the observed EOIs with maternal environment. The applied perinatal antibiotic prophylaxis was ineffective.
Authors:
Jadwiga Wójkowska-Mach; Maria Borszewska-Kornacka; Joanna Domańska; Janusz Gadzinowski; Ewa Gulczyńska; Ewa Helwich; Agnieszka Kordek; Dorota Pawlik; Jerzy Szczapa; Piotr B Heczko
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Microbiology, Jagiellonian University Medical College, Krakow 2 Clinic of Neonatology and Intensive Neonatal Care, Warsaw Medical University, Warszawa 3 Institute of Theoretical and Applied Informatics of Polish Academy of Sciences, Gliwice 4 Department of Neonatology, Poznan University of Medical School 5 Clinic of Neonatology, Polish Mother's Memorial Hospital-Research Institute, Lodz 6 Clinic of Neonatology and Intensive Neonatal Care, Institute of Mother and Child, Warszawa 7 Department of Neonatal Diseases, Pomeranian Medical University, Szczecin 8 Clinic of Neonatology, Jagiellonian University Medical College, Krakow.
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