Document Detail

Early NT-proBNP Is Able to Predict Spontaneous Closure of Patent Ductus Arteriosus in Preterm Neonates, But Not the Need of Its Treatment.
MedLine Citation:
PMID:  21656237     Owner:  NLM     Status:  Publisher    
The objective of this study was to establish the potential utility of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the management of patent ductus arteriosus (PDA). This was a monocentric prospective blind study that was conducted in a referral neonatal intensive care unit. The patients were very low-birth-weight/gestational-age neonates. Babies with cardiac congenital anomaly other than PDA, life-threatening congenital malformation, severe asphyxia at birth, persistent pulmonary hypertension, and death within the first week of life were excluded. Plasma NT-proBNP concentrations were determined on days 2, 4, and 7 of life. Echocardiography was performed on days 4 and 7. Results were blinded to clinicians. Only echographic results were available upon request. Thirty-one infants were included. NT-proBNP levels were significantly correlated to ductal size and to left atrial-to-aortic diameter ratio. The median NT-proBNP on both days 2 and 4 was significantly higher in neonates with later treated or persistent PDA. A level above 10.000 pg/mL at 48 h of age yielded a 100% positive and a 87% negative predictive value to exclude spontaneous ductal closure. However, no NT-proBNP threshold could predict which PDA would be judged necessary to treat. It was concluded that early low NT-proBNP values can be used as a reliable independent marker to predict spontaneous ductal closure in preterm neonates. Yet, high NT-proBNP levels should not be used to guide the decision to treat PDA, the risk being of treating many bystanding PDAs.
D Martinovici; S Vanden Eijnden; P Unger; B Najem; B Gulbis; Y Maréchal
Related Documents :
21702877 - Effects of infant massage on hiv-infected mothers and their infants.
21641117 - Impact of a prenatal cognitive-behavioral stress management intervention on salivary co...
21856517 - Reduction of unnecessary intake of water and herbal teas on breast-fed infants: a rando...
21670927 - Lopinavir/ritonavir dosing during pregnancy in brazil and maternal/infant laboratory ab...
17353027 - Photocatalytic degradation of reactive black 5 in aqueous solutions: effect of operatin...
6642437 - Effects of neonatal estrogen treatment of female guinea pigs on mounting behavior in ad...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-9
Journal Detail:
Title:  Pediatric cardiology     Volume:  -     ISSN:  1432-1971     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Neonatal Intensive Care Unit, ULB-Erasme Hospital, 808 Route de Lennik, 1070, Brussels, Belgium,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Autologous Right Pulmonary Artery Tissue for Repair of Left Pulmonary Artery Originating from Left P...
Next Document:  Establishment of Secondary Iron Overloaded Mouse Model: Evaluation of Cardiac Function and Analysis ...