Document Detail

Early myocardial deformation changes associated to isolated obesity: a study based on 3D-wall motion tracking analysis.
MedLine Citation:
PMID:  21720437     Owner:  NLM     Status:  MEDLINE    
Obesity is considered as a strong risk factor for cardiovascular morbidity and mortality. 3D-wall motion tracking echocardiography (3D-WMT) provides information regarding different parameters of left ventricular (LV) myocardial deformation. Our aim was to assess the presence of early myocardial deformation abnormalities in nonselected obese children free from other cardiovascular risk factors. Thirty consecutive nonselected obese children and 42 healthy volunteer children were enrolled. None of them had any cardiovascular risk factor. Every subject underwent a 2D-echo examination and a 3D-WMT study. Mean age was 13.9 ± 2.56 and 13.25 ± 2.68 years in the nonobese and obese groups, respectively (59.7% and 40.3% male). Statistically significant differences were found for: interventricular septum thickness, LV posterior wall thickness, LV end-diastolic volume, LV end-systolic volume, left atrium volume, LV mass, and lateral annulus peak velocity. Regarding the results obtained by 3D-WMT assessment, all the evaluated parameters were statistically significantly different between the two groups. When the influence of obesity on the different echocardiographic variables was evaluated by means of multivariate logistic regression analysis, the strongest relationship with obesity was found for LV average circumferential strain (β-coefficient: 0.74; r(2): 0.55; P: 0.003). Thus, obesity cardiomyopathy is associated not only with structural cardiac changes, but also with myocardial deformation changes. Furthermore, this association occurs as early as in the childhood and it is independent from any other cardiovascular risk factor. The most related parameter to obesity is LV circumferential strain.
Adriana Saltijeral; Leopoldo Pérez de Isla; Olga Pérez-Rodríguez; Santiago Rueda; Covadonga Fernandez-Golfin; Carlos Almeria; Jose L Rodrigo; Willem Gorissen; Juan Rementeria; Pedro Marcos-Alberca; Carlos Macaya; Jose Zamorano
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Publication Detail:
Type:  Journal Article     Date:  2011-06-30
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-27     Completed Date:  2012-02-24     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2268-73     Citation Subset:  IM    
Cardiology Department, Hospital Clínico San Carlos, Madrid, Spain.
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MeSH Terms
Cardiomyopathies / complications,  ultrasonography
Cardiovascular Diseases / complications,  ultrasonography*
Echocardiography, Three-Dimensional / methods*
Linear Models
Logistic Models
Multivariate Analysis
Myocardium / pathology
Obesity / complications,  physiopathology*,  ultrasonography*
Prospective Studies
Risk Factors
Ventricular Dysfunction, Left / physiopathology,  ultrasonography

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