| Early Maternal Serum β-human Chorionic Gonadotropin Measurements After ICSI in the Prediction of Long-term Pregnancy Outcomes: A Retrospective Cohort Analysis. | |
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MedLine Citation:
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PMID: 22043269 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Initial low maternal serum β-human chorionic gonadotropin (β-hCG) is a good predictor of early pregnancy demise. Our objective was to determine its predictive value in determining the long-term outcome in ICSI pregnancies. METHODS: A retrospective cohort study was designed at the Saudi Center for Assisted Reproduction. Two hundred and sixty-one women with ICSI pregnancies were followed up from initial β-hCG level determination till the end of pregnancy. Accuracy of early β-hCG in predicting the occurrence of a live-birth, ongoing pregnancy, late miscarriage, ectopic pregnancy and early miscarriage following ICSI was measured. RESULTS: β-hCG levels were significantly different in pregnancies that reached the stage of an ongoing pregnancy and live-birth as compared to early pregnancy loss. The ROC curves demonstrated a high sensitivity for identifying patients with ectopic pregnancies and early miscarriage (100% and 93.33% respectively). The remaining results ranged from a sensitivity of 69% to 79% and specificity of 62% to 75%. CONCLUSIONS: In ICSI pregnancies, a single early β-hCG may help to identify pregnancies that will reach full-term and delivery. KEYWORDS: ICSI; Human chorionic gonadotropin; Outcome; Pregnancy. |
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Authors:
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Mamdoh A Eskandar; Mesfer Al-Shahrani; Ayman Shaamash; Mohamed El-Emain; Mutaz Al-Ahmad; Beverly Payodon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical medicine research Volume: 3 ISSN: 1918-3011 ISO Abbreviation: J Clin Med Res Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-11-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101538301 Medline TA: J Clin Med Res Country: Canada |
Other Details:
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Languages: eng Pagination: 30-5 Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology and Reproductive Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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