Document Detail

Early maternal hyperleptinemia programs adipogenic phenotype in rats.
MedLine Citation:
PMID:  19685418     Owner:  NLM     Status:  MEDLINE    
We have previously reported on the treatment of maternal rats with leptin during the three last days of lactation program for overweight and leptin hypothalamic resistance in the offspring. Here we have investigated whether treatment of maternal rats with leptin in the first ten days of lactation can program metabolic dysfunctions on the adult offspring. Lactating rats were divided into 2 groups: rats (LEP) injected with recombinant mouse leptin (8 microg/100 g/body weight, daily during the first 10 days of lactation) and control group (C) that received the same volume of saline. After weaning, all pups had free access to normal diet, their body weight and food intake were monitored at 4 days interval until 180 days, when they were tested for food intake and response to either leptin (0.5 mg/kg body weight, ip) or saline. The offspring from leptin-treated mothers gained more weight from day 69 onward and had higher food intake from day 145 onward, higher amount of visceral adipose tissue (57%), higher serum glucose (10%), and higher serum leptin (135%) at 180 days compared to control group. The food intake was not reduced as expected after acute injection of leptin in these animals, suggesting resistance to the anorexigenic effect of leptin. We conclude that maternal hyperleptinemia in early lactation programed higher food intake, body weight gain due to higher total and visceral fat mass, and resistance to anorexigenic effect of leptin in the adult offspring even when this hyperleptinemia occurred at the beginning of lactation.
F Pereira-Toste; F P Toste; E Oliveira; P A Trotta; P C Lisboa; E G de Moura; M C F Passos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-14
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme     Volume:  41     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  874-9     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart. New York.
Department of Physiological Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Adipogenesis / drug effects,  physiology*
Adiposity / drug effects
Animals, Newborn
Blood Glucose / drug effects
Body Weight / drug effects
Feeding Behavior / drug effects
Insulin / blood
Insulin Resistance
Lactation / drug effects
Leptin / administration & dosage,  blood,  pharmacology*
Maternal Exposure*
Maternal Nutritional Physiological Phenomena
Nutritional Status / drug effects
Reg. No./Substance:
0/Blood Glucose; 0/Leptin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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