Document Detail

Early Life Origins of Adult Disease and Maternal Smoking During Pregnancy.
MedLine Citation:
PMID:  22698037     Owner:  NLM     Status:  Publisher    
Johnson and Shoeni examined the relation between low birth weight (LBW) and childhood family socioeconomic disadvantage and disease onset in adulthood.(1) They report that LBW independently predicted asthma, hypertension, diabetes, and cardiovascular diseases by age 50 years. Disease prevalence was influenced also by childhood socioeconomic (SES) status. They conclude that these findings are consistent with the fetal origins hypothesis, which posits that adverse in utero influences increases the risk of disease later in life. We would like to stress the likely mediating effect of maternal smoking during pregnancy. In the study by Johnson and Shoeni, the smoking variable, parental smoking, increased disease risk in adulthood in univariate but not in multivariate analyses probably because it lacks specification (i.e., it did not distinguish which parent was a smoker and whether the mother smoked or not during her pregnancy). (Am J Public Health. Published online ahead of print June 14, 2012: e1. doi:10.2105/AJPH.2012.300650).
Henri-Jean Aubin; Ivan Berlin; Michel Reynaud
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  American journal of public health     Volume:  -     ISSN:  1541-0048     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Henri-Jean Aubin and Michel Reynaud are with Hôpital Paul Brousse, Univ Paris-Sud, INSERM U669, Villejuif, France. Ivan Berlin is with Hôpital Pitié-Salpêtrière, Univ PMC, Paris, France.
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