Document Detail

Early life exposure to the 1959-1961 Chinese famine has long-term health consequences.
MedLine Citation:
PMID:  20702751     Owner:  NLM     Status:  MEDLINE    
The Chinese famine of 1959-1961 was the largest in human history. We used data on 35,025 women born in 1957-1963 to assess the impact of famine exposure on height, BMI, and hypertension at ~32 y of age. The data were from the China-U.S. Collaborative Project for Neural Tube Defect Prevention. The famine varied in intensity across provinces and counties and affected rural areas disproportionately. We used a measure of famine intensity at the county level based on the size of birth year cohorts in a difference-in-difference model, which compared each cohort to the unexposed 1963 cohort, after correcting for age and time trends, and estimated impact for the average level of intensity across counties. The impact was confined to rural areas, but this could be due to small sample sizes in urban areas. Height was reduced in the 1958 and 1959 cohorts by 1.7 and 1.3 cm, respectively. This corresponded to exposures during 0.5-3.5 y for the 1958 cohort and late pregnancy and 0-2.5 y for the 1959 cohort. BMI increased by 0.92 kg/m(2) in the 1957 cohort, exposed from 1.5 to 4.5 y, but decreased by 0.3 kg/m(2) in the 1960-1961 cohorts, exposed during pregnancy and infancy. Famine exposure was associated with a 3-fold increase in the odds of hypertension for the 1958 cohort. In general, postnatal exposure during the first 2-3 y of life reduced height and increased BMI and hypertension, whereas exposure during pregnancy and infancy reduced BMI.
Cheng Huang; Zhu Li; Meng Wang; Reynaldo Martorell
Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-11
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1874-8     Citation Subset:  IM    
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Body Height*
Body Mass Index*
Child Nutritional Physiological Phenomena
Child, Preschool
China / epidemiology
Disasters / history
Food Supply / history
History, 20th Century
Hypertension / epidemiology*,  etiology*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Prenatal Exposure Delayed Effects
Rural Population
Starvation / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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