| Early left ventricular mechanics abnormalities in prehypertension: a two-dimensional strain echocardiography study. | |
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MedLine Citation:
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PMID: 20044741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Prehypertension predicts established hypertension. In this study, the aim was to analyze left ventricular (LV) mechanics in borderline prehypertensive (pre-HT) and hypertensive (HT) subjects through two-dimensional (2D)-strain echocardiography and then evaluate possible relations between cardiac parameters and insulin metabolism (homeostasis model assessment of insulin resistance (HOMA(IR)). METHODS: Seventy-four consecutive newly diagnosed, untreated HT were divided, on the basis of their office blood pressure (BP) measurements, confirmed by ambulatory BP monitoring (ABPM), in 41 borderline pre-HT (ABPM: 122.5 +/- 6.7/76.2 +/- 5.2 mm Hg) and 33 never-treated mild HT (ABPM: 138.3 +/- 7.3/87.6 +/- 7.1 mm Hg). Thirty-three healthy normotensive (NT) controls (ABPM: 114.8 +/- 6.3/73.1 +/- 6.1 mm Hg) (P < 0.0001) were also studied (NT). All subjects performed 2D color Doppler and pulsed-wave tissue Doppler imaging (PW-TDI). RESULTS: Left ventricular mass (LVM) was significantly higher in pre-HT (39.2 +/- 8.7 g/m(2.7)) and in HT (43.6 +/- 8.5 g/m(2.7)) compared with NT (30.9 +/- 7.4 g/m(2.7)) (P < 0.0001). A mild LV diastolic dysfunction was found both with Doppler mitral flow velocity and PW-TDI at mitral annulus level analysis. Longitudinal 2D strain in pre-HT (-18.9% +/- 3.4) and in HT (-18.0% +/- 3.3) was significantly lower than in NT (-23.9% +/- 3.0) (P < 0.002). These LV abnormalities were associated with systolic ABPM, LVM, and HOMA(IR). CONCLUSIONS: Early abnormalities of LV longitudinal systolic deformation were found both in pre-HT and HT, together with a mild LV diastolic dysfunction. In both groups this early cardiac systolic and diastolic dysfunction is associated to insulin resistance, systolic pressure load, and cardiac remodeling. |
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Authors:
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Vitantonio Di Bello; Enrica Talini; Giulia Dell'Omo; Cristina Giannini; Maria Grazia Delle Donne; Maria Laura Canale; Carmela Nardi; Caterina Palagi; Frank Lloyd Dini; Giuseppe Penno; Stefano Del Prato; Mario Marzilli; Roberto Pedrinelli |
Publication Detail:
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Type: Journal Article Date: 2009-12-31 |
Journal Detail:
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Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-06-04 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Affiliation:
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Cardiac and Thoracic and Vascular Department, University of Pisa, Pisa, Italy. vdibello@med.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Blood Pressure Determination Cholesterol / blood Echocardiography Female Humans Hypertension / blood, physiopathology, ultrasonography* Hypertrophy, Left Ventricular / physiopathology, ultrasonography Insulin / blood Insulin Resistance Male Middle Aged Triglycerides / blood Ventricular Dysfunction, Left / ultrasonography* Ventricular Remodeling |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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