| Early inflammatory response in patients with ruptured abdominal aortic aneurysm. | |
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MedLine Citation:
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PMID: 19917558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiorgan failure is the main cause of death in patients operated for ruptured abdominal aortic aneurysm (rAAA). The systemic inflammatory response plays a central role in the generation and maintenance of multiorgan dysfunction. The aim of the current study was to investigate the inflammatory response preoperatively in patients with ruptured and nonruptured AAA in relation to the clinical outcome. A total of 95 patients about to undergo repair of AAA (43 ruptured with shock, 12 ruptured without shock, and 40 elective) and 41 controls without aneurysm matched by age, gender, and smoking habits were investigated by inflammatory markers. There were significantly higher levels of interleukin 6 (IL-6; proinflammatory cytokine) and IL-10 (anti-inflammatory cytokine) in patients operated for ruptured compared to nonruptured AAA. In conclusion, the current data indicate that rupture of an AAA activates the inflammatory system with a compensatory anti-inflammatory response. |
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Authors:
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Jonas Wallinder; Elisabet Skagius; David Bergqvist; Anders E Henriksson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-16 |
Journal Detail:
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Title: Vascular and endovascular surgery Volume: 44 ISSN: 1938-9116 ISO Abbreviation: Vasc Endovascular Surg Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136421 Medline TA: Vasc Endovascular Surg Country: United States |
Other Details:
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Languages: eng Pagination: 32-5 Citation Subset: IM |
Affiliation:
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Department of Surgery, Sundsvall County Hospital, Sweden. jonas.wallinder@lvn.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Aneurysm, Abdominal / complications, immunology, mortality, surgery* Aortic Rupture / etiology, immunology, mortality, surgery* Biological Markers / blood Case-Control Studies Chemokine CCL2 / blood Female Hospital Mortality Humans Inflammation Mediators / blood* Interleukin-10 / blood Interleukin-6 / blood Male Middle Aged Prospective Studies Systemic Inflammatory Response Syndrome / etiology*, immunology, mortality Time Factors Treatment Outcome Vascular Surgical Procedures / adverse effects*, mortality |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CCL2 protein, human; 0/Chemokine CCL2; 0/IL10 protein, human; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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