Document Detail

Early inflammatory response in patients with ruptured abdominal aortic aneurysm.
MedLine Citation:
PMID:  19917558     Owner:  NLM     Status:  MEDLINE    
Multiorgan failure is the main cause of death in patients operated for ruptured abdominal aortic aneurysm (rAAA). The systemic inflammatory response plays a central role in the generation and maintenance of multiorgan dysfunction. The aim of the current study was to investigate the inflammatory response preoperatively in patients with ruptured and nonruptured AAA in relation to the clinical outcome. A total of 95 patients about to undergo repair of AAA (43 ruptured with shock, 12 ruptured without shock, and 40 elective) and 41 controls without aneurysm matched by age, gender, and smoking habits were investigated by inflammatory markers. There were significantly higher levels of interleukin 6 (IL-6; proinflammatory cytokine) and IL-10 (anti-inflammatory cytokine) in patients operated for ruptured compared to nonruptured AAA. In conclusion, the current data indicate that rupture of an AAA activates the inflammatory system with a compensatory anti-inflammatory response.
Jonas Wallinder; Elisabet Skagius; David Bergqvist; Anders E Henriksson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-16
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  44     ISSN:  1938-9116     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
Department of Surgery, Sundsvall County Hospital, Sweden.
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MeSH Terms
Aortic Aneurysm, Abdominal / complications,  immunology,  mortality,  surgery*
Aortic Rupture / etiology,  immunology,  mortality,  surgery*
Biological Markers / blood
Case-Control Studies
Chemokine CCL2 / blood
Hospital Mortality
Inflammation Mediators / blood*
Interleukin-10 / blood
Interleukin-6 / blood
Middle Aged
Prospective Studies
Systemic Inflammatory Response Syndrome / etiology*,  immunology,  mortality
Time Factors
Treatment Outcome
Vascular Surgical Procedures / adverse effects*,  mortality
Reg. No./Substance:
0/Biological Markers; 0/CCL2 protein, human; 0/Chemokine CCL2; 0/IL10 protein, human; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 130068-27-8/Interleukin-10

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