Document Detail


Early improvement in peripheral vascular tone following smoking cessation using nicotine replacement therapy: aortic wave reflection analysis.
MedLine Citation:
PMID:  20881393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Cigarette smoking induces cardiovascular pathology and worsens arterial stiffness. Arterial stiffness can be assessed noninvasively based on 2 indices: pulse-wave velocity (PWV), indicating aortic stiffness, and the augmentation index (AIx), indicating aortic wave reflection. The impact of smoking cessation (SC) with nicotine replacement therapies (NRT) on arterial stiffness remains unknown.
METHODS: AIx and PWV were studied prospectively (using a SphygmoCor system) in 26 long-term smokers (>10 cigarettes/day; mean age 43 ± 6 years) before (visit 1) and 28 and 56 days (visit 2 and visit 3) after SC supported by NRT. Abstinence was ascertained when exhaled carbon monoxide (CO) was <10 ppm; the quantity of NRT absorbed was assessed based on the serum cotinine level.
RESULTS: Sixteen of 24 patients (67%) were abstinent at the end of the study; 8/24 had cut down on smoking, and 2 were lost to follow-up. CO and serum cotinine levels fell after SC. The mean AIx for the population as a whole was 23.4% at visit 1, with a significant early reduction by visit 2 (16.2%) and visit 3 (13.9%) (ANOVA, p < 0.001). The PWV, peripheral blood pressure, and heart rate were unchanged.
CONCLUSIONS: The improvement in AIx and the stability of PWV after SC with NRT indicate improved peripheral vascular tone. This impact may account for the early clinical benefit of SC observed even when associated with NRT.
Authors:
Antoine Roux; Pascal Motreff; Jean Perriot; Bruno Pereira; Jean-René Lusson; Christian Duale; Dominique Morand; Claude Dubray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-30
Journal Detail:
Title:  Cardiology     Volume:  117     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-01-31     Revised Date:  2011-02-11    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Pôle Cardiologie, CHU Clermont-Ferrand, Clermont-Ferrand, France. anroux@chu-clermontferrand.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aorta / physiology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology
Female
Heart Rate / physiology
Humans
Male
Middle Aged
Nicotine / administration & dosage*
Nicotinic Agonists / administration & dosage
Prospective Studies
Pulsatile Flow / physiology*
Recovery of Function / physiology
Smoking Cessation / methods*
Vasoconstriction / physiology*
Chemical
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine
Comments/Corrections
Comment In:
Cardiology. 2010;117(3):181-3   [PMID:  21071939 ]

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