Document Detail

Early hyperglycemia is a risk factor for death and white matter reduction in preterm infants.
MedLine Citation:
PMID:  20176674     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to determine whether hyperglycemia during the first week of life in extremely preterm (EPT) infants was associated with increased mortality rates and with cerebral injury, as assessed with MRI of the brain, at term-equivalent age. METHODS: All 143 EPT infants (gestational ages of <27 weeks) who were born at Karolinska University Hospital between January 2004 and December 2006 and were alive at 24 hours were eligible. Of the 118 surviving infants, 24 were excluded for various reasons. MRI was performed for the 94 included survivors at term age, with a 1.5-T system, and scans were scored for gray matter/white matter (WM) abnormalities. Of the 25 infants who died before term age, 6 were excluded because of missing glucose documentation and the remaining 19 were included. Hyperglycemia was defined as plasma glucose levels of >8.3 mmol/L. RESULTS: Hyperglycemia occurring on the first day of life was identified as an independent risk factor for death (adjusted odds ratio: 3.7 [95% confidence interval: 1.3-10.6]; P = .01). Hyperglycemia occurring on the first day of life also was a risk factor for WM reduction, as determined through MRI, at term-equivalent age (adjusted odds ratio: 3.1 [95% confidence interval: 1.0-9.2]; P = .04). CONCLUSION: In this population-based cohort of EPT infants, hyperglycemia on the first day of life was associated with increased mortality rates and brain damage, as reflected by WM reduction at term age.
Georgios Alexandrou; Beatrice Ski?ld; Jonna Karl?n; Mesfin K Tessma; Mikael Norman; Ulrika Ad?n; Mireille Vanp?e
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-22
Journal Detail:
Title:  Pediatrics     Volume:  125     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e584-91     Citation Subset:  AIM; IM    
Neonatal Unit, Astrid Lindgren Children's Hospital/Karolinska University Hospital, SE-171 77 Stockholm, Sweden.
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MeSH Terms
Age Factors
Brain Diseases / diagnosis,  etiology*
Hyperglycemia / complications*,  mortality*
Infant, Newborn
Infant, Premature, Diseases / mortality*
Magnetic Resonance Imaging
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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