Document Detail


Early high pulse pressure is associated with graft dysfunction and predicts poor kidney allograft survival.
MedLine Citation:
PMID:  19898204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pulse pressure (PP), which reflects the pulsatile component of the blood pressure (BP), is known as a major predictor of cardiovascular events and death. In the elderly and type 2 diabetic patients, PP is associated with low glomerular filtration rate and albuminuria. Because kidney allograft survival is closely related to BP levels, we investigated the impact of early high PP, systolic, diastolic, and mean arterial BP on kidney allograft survival. METHODS: Renal hemodynamic and function studies using isotopic methods were prospectively performed in 493 renal transplant patients at 3 months posttransplantation to determine the impact of the different BP components on allograft survival using a proportional hazard model. RESULTS: After a median follow-up of 6.3 years, 91 allografts were lost. High PP was associated with high systolic, diastolic, and mean arterial pressure, heart rate, recipient age, glycemia, and low glomerular filtration rate. Moreover, PP emerged as the strongest BP component influencing overall and death-censored kidney allograft survival. CONCLUSION: High PP is an early marker of poor allograft outcome that could be corrected by therapeutic intervention.
Authors:
Fernando Vetromile; Ilan Szwarc; Val??rie Garrigue; Sylvie Delmas; Pierre Fesler; Albert Mimran; Jean Ribstein; Georges Mourad
Related Documents :
7811784 - The relationship between 24-hour ambulatory blood pressures and laboratory measures of ...
15087554 - Stress-induced blood pressure reactivity and silent cerebrovascular disease.
18223194 - Postural-induced phase shift of respiratory sinus arrhythmia and blood pressure variati...
22929654 - Disruption of splenic circulation using microbubble-enhanced ultrasound and prothrombin...
17552684 - Liquid jet response to internal modulated ultrasonic radiation pressure and stimulated ...
17116454 - Basic ventilator management: lung protective strategies.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  88     ISSN:  1534-6080     ISO Abbreviation:  Transplantation     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1088-94     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Transplantation, H??pital Lapeyronie, University of Montpellier, Montpellier, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Albuminuria / epidemiology
Cadaver
Creatinine / blood
Diastole
Follow-Up Studies
Glomerular Filtration Rate
Heart Rate / physiology*
Humans
Hypertension / epidemiology*
Kidney Diseases / classification,  surgery
Kidney Transplantation / adverse effects,  mortality*,  physiology*
Postoperative Complications / epidemiology
Predictive Value of Tests
Renal Circulation
Retrospective Studies
Survival Rate
Systole
Tissue Donors
Transplantation, Homologous / adverse effects,  mortality,  physiology
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rapamycin for refractory acute graft-versus-host disease.
Next Document:  Mycophenolate mofetil use is associated with prolonged graft survival after kidney transplantation.