Document Detail

Early high pulse pressure is associated with graft dysfunction and predicts poor kidney allograft survival.
MedLine Citation:
PMID:  19898204     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulse pressure (PP), which reflects the pulsatile component of the blood pressure (BP), is known as a major predictor of cardiovascular events and death. In the elderly and type 2 diabetic patients, PP is associated with low glomerular filtration rate and albuminuria. Because kidney allograft survival is closely related to BP levels, we investigated the impact of early high PP, systolic, diastolic, and mean arterial BP on kidney allograft survival. METHODS: Renal hemodynamic and function studies using isotopic methods were prospectively performed in 493 renal transplant patients at 3 months posttransplantation to determine the impact of the different BP components on allograft survival using a proportional hazard model. RESULTS: After a median follow-up of 6.3 years, 91 allografts were lost. High PP was associated with high systolic, diastolic, and mean arterial pressure, heart rate, recipient age, glycemia, and low glomerular filtration rate. Moreover, PP emerged as the strongest BP component influencing overall and death-censored kidney allograft survival. CONCLUSION: High PP is an early marker of poor allograft outcome that could be corrected by therapeutic intervention.
Fernando Vetromile; Ilan Szwarc; Val??rie Garrigue; Sylvie Delmas; Pierre Fesler; Albert Mimran; Jean Ribstein; Georges Mourad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  88     ISSN:  1534-6080     ISO Abbreviation:  Transplantation     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1088-94     Citation Subset:  IM    
Department of Nephrology and Transplantation, H??pital Lapeyronie, University of Montpellier, Montpellier, France.
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MeSH Terms
Albuminuria / epidemiology
Creatinine / blood
Follow-Up Studies
Glomerular Filtration Rate
Heart Rate / physiology*
Hypertension / epidemiology*
Kidney Diseases / classification,  surgery
Kidney Transplantation / adverse effects,  mortality*,  physiology*
Postoperative Complications / epidemiology
Predictive Value of Tests
Renal Circulation
Retrospective Studies
Survival Rate
Tissue Donors
Transplantation, Homologous / adverse effects,  mortality,  physiology
Reg. No./Substance:

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