Document Detail

Early Head Growth in Infants at Risk of Autism: A Baby Siblings Research Consortium Study.
MedLine Citation:
PMID:  25245349     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Although early brain overgrowth is frequently reported in autism spectrum disorder (ASD), the relationship between ASD and head circumference (HC) is less clear, with inconsistent findings from longitudinal studies that include community controls. Our aim was to examine whether head growth in the first 3 years differed between children with ASD from a high-risk (HR) sample of infant siblings of children with ASD (by definition, multiplex), HR siblings not diagnosed with ASD, and low-risk (LR) controls.
METHOD: Participants included 442 HR and 253 LR infants from 12 sites of the international Baby Siblings Research Consortium. Longitudinal HC data were obtained prospectively, supplemented by growth records. Random effects nonlinear growth models were used to compare HC in HR infants and LR infants. Additional comparisons were conducted with the HR group stratified by diagnostic status at age 3: ASD (n = 77), developmental delay (DD; n = 32), and typical development (TD; n = 333). Nonlinear growth models were also developed for height to assess general overgrowth associated with ASD.
RESULTS: There was no overall difference in head circumference growth over the first 3 years between HR and LR infants, although secondary analyses suggested possible increased total growth in HR infants, reflected by the model asymptote. Analyses stratifying the HR group by 3-year outcomes did not detect differences in head growth or height between HR infants who developed ASD and those who did not, nor between infants with ASD and LR controls.
CONCLUSION: Head growth was uninformative as an ASD risk marker within this HR cohort.
Lonnie Zwaigenbaum; Gregory S Young; Wendy L Stone; Karen Dobkins; Sally Ozonoff; Jessica Brian; Susan E Bryson; Leslie J Carver; Ted Hutman; Jana M Iverson; Rebecca J Landa; Daniel Messinger
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Publication Detail:
Type:  Journal Article     Date:  2014-08-07
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  53     ISSN:  1527-5418     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-09-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1053-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
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