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Early First-Trimester Crown-Rump Length Measurements in Male and Female Singleton Fetuses in IVF Pregnancies.
MedLine Citation:
PMID:  22827560     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objectives: The generally higher birth-weight of male newborns compared to female newborns is attributed mainly to intrauterine exposure to testosterone. We aimed to determine if crown-rump length (CRL) differs between male and female fetuses early in the first trimester. Methods: A retrospective cohort study of 333 women with non-diabetic singleton IVF pregnancies attending a single university-affiliated tertiary medical center in 2000-2007 who underwent CRL measurement before 50 days of pregnancy (date of measurement minus oocyte retrieval date plus 14 days). Data on pregnancy outcome, including fetal sex, were collected by routine follow-up telephone interview and combined with the delivery data. Results: There were 169 female and 164 male fetuses according to the reported fetal sex at delivery. Most of the CRL measurements (68.7%) were performed at an actual gestational age of 43-45 days. On linear regression analysis, male fetal sex was a significant (p=0.011) predictor of larger CRL: CRL (mm) = -23.851+GA(days)*0.621+0.334*SEX(F=1,M=2), R(2)=0.512, <0.001. A general linear model, adjusted for gestational age (40-50 days), revealed that mean CRL was significantly higher in male than in female fetuses (4.58±0.09 mm, [95% CI 4.3-4.7] vs 4.24±0.09 mm [4.0-4.4]; p<0.001). Conclusions: Male fetuses are larger than female fetuses in the early first trimester. Given that gonadal differentiation has not yet occurred, still unidentified non-hormonal factors are apparently responsible for this difference.
Authors:
Avi Ben-Haroush; Nir Melamed; Galia Oron; Israel Meizner; Benjamin Fisch; Marek Glezerman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-24
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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