| Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice. | |
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MedLine Citation:
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PMID: 22423048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mouse and human pregnancy-specific glycoproteins (PSG) are known to exert immunomodulatory functions during pregnancy by inducing maternal leukocytes to secrete anti-inflammatory cytokines that promote a tolerogenic decidual microenvironment. Many such anti-inflammatory mediators also function as proangiogenic factors, which, along with the reported association of murine PSG with the uterine vasculature, suggest that PSG may contribute to the vascular adaptations necessary for successful implantation and placental development. We observed that PSG22 is strongly expressed around the embryonic crypt on Gestation Day 5.5, indicating that trophoblast giant cells are the main source of PSG22 during the early stages of pregnancy. PSG22 treatment up-regulated the secretion of transforming growth factor beta 1 and vascular endothelial growth factor A (VEGFA) in murine macrophages, uterine dendritic cells, and natural killer cells. A possible role of PSGs in uteroplacental angiogenesis is further supported by the finding that incubation of endothelial cells with PSG22 resulted in the formation of tubes in the presence and absence of VEGFA. We determined that PSG22, like human PSG1 and murine PSG17 and PSG23, binds to the heparan sulfate chains in syndecans. Therefore, our findings indicate that despite the independent evolution and expansion of human and rodent PSG, members in both families have conserved functions that include their ability to induce anti-inflammatory cytokines and proangiogenic factors as well as to induce the formation of capillary structures by endothelial cells. In summary, our results indicate that PSG22, the most abundant PSG expressed during mouse early pregnancy, is likely a major contributor to the establishment of a successful pregnancy. |
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Authors:
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Sandra M Blois; Irene Tirado-González; Julie Wu; Gabriela Barrientos; Briana Johnson; James Warren; Nancy Freitag; Burghard F Klapp; Ster Irmak; Suleyman Ergun; Gabriela S Dveskler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-06-28 |
Journal Detail:
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Title: Biology of reproduction Volume: 86 ISSN: 1529-7268 ISO Abbreviation: Biol. Reprod. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-29 Completed Date: 2012-10-16 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: United States |
Other Details:
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Languages: eng Pagination: 191 Citation Subset: IM |
Affiliation:
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Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Medicine Research Group, University Medicine of Berlin, Berlin, Germany. sandra.blois@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD9 / metabolism CHO Cells Cricetinae Cricetulus Dendritic Cells / metabolism Female Glycoproteins / metabolism* Killer Cells, Natural / metabolism Macrophages / metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Neovascularization, Physiologic* Pregnancy Pregnancy Proteins / metabolism* Pregnancy, Animal / immunology, metabolism* Recombinant Proteins / metabolism Syndecans / metabolism Transforming Growth Factor beta / metabolism Trophoblasts / metabolism* Vascular Endothelial Growth Factor A / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01HD035832/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD9; 0/Cd9 protein, mouse; 0/Glycoproteins; 0/Pregnancy Proteins; 0/Psg-22 protein, mouse; 0/Recombinant Proteins; 0/Syndecans; 0/Transforming Growth Factor beta; 0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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