Document Detail

Early diagnostic markers for contrast nephropathy in patients undergoing coronary angiography.
MedLine Citation:
PMID:  20529972     Owner:  NLM     Status:  MEDLINE    
The present work aimed to prove the usage of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for kidney injury and to assess the relationship between NGAL and serum creatinine and cystatin C in patients with normal serum creatinine undergoing percutaneous coronary angiography. Thirty patients with normal serum creatinine undergoing coronary angiography were enrolled. Estimation of blood glucose, glycosylated hemoglobin, lipid profile, creatinine, NGAL, and cystatin C were done before coronary angiography for all patients. Serum creatinine, NGAL and cystatin C were evaluated again at 4 and 24 hours after coronary angiography. There was a significant increase in serum NGAL level 4 hours and 24 hours after coronary interventions compared to the baseline value before coronary angiography. Before coronary angiography, serum NGAL was positively correlated with serum creatinine, and cystatin C. Conclusion: Serum NGAL and cystatin C could be valuable in the detection of early renal impairment after coronary angiography.
Olfat G Shaker; Amal El-Shehaby; Mohamed El-Khatib
Publication Detail:
Type:  Journal Article     Date:  2010-06-07
Journal Detail:
Title:  Angiology     Volume:  61     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  731-6     Citation Subset:  IM    
Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Egypt.
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MeSH Terms
Acute-Phase Proteins
Biological Markers / blood
Contrast Media / adverse effects*
Coronary Angiography*
Creatinine / blood*
Cystatin C / blood*
Kidney Diseases / chemically induced*,  diagnosis*
Lipocalins / blood*
Middle Aged
Proto-Oncogene Proteins / blood*
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/Contrast Media; 0/Cystatin C; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 60-27-5/Creatinine
Comment In:
Angiology. 2010 Nov;61(8):721-3   [PMID:  20682609 ]

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