Document Detail

Early diagnosis and treatment of cobalamin deficiency of infancy owing to occult maternal pernicious anemia.
MedLine Citation:
PMID:  20404749     Owner:  NLM     Status:  MEDLINE    
We report case of an infant who presented with failure to thrive and developmental delay at 4 months of age. He was diagnosed to have vitamin B12 deficiency and antibodies to intrinsic factor secondary to undiagnosed maternal pernicious anemia. The child was treated with hydroxocobalamin and now at 2 years of age, he is developing and growing within normal range. We review the literature on this rare cause of cobalamin deficiency in infants. We highlight the factors determining the outcome and situations where raised index of suspicion could help in recognizing this preventable cause of developmental delay and learning difficulties.
Siddharth Banka; Ruth Roberts; Dianne Plews; William G Newman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  32     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-05-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-22     Citation Subset:  IM    
Academic Unit of Medical Genetics, University of Manchester, Manchester, UK.
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MeSH Terms
Anemia, Pernicious / complications*
Early Diagnosis
Failure to Thrive
Hydroxocobalamin / therapeutic use
Treatment Outcome
Vitamin B 12 Deficiency / diagnosis*,  drug therapy,  etiology*
Vitamin B Complex / therapeutic use
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 13422-51-0/Hydroxocobalamin

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