Document Detail


Early changes in myocardial microcirculation in asymptomatic hypercholesterolemic subjects: as detected by perfusion CT.
MedLine Citation:
PMID:  24232745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intramyocardial microvessels show functional changes in early stages of atherosclerosis prior to epicardial coronary artery stenosis. However, clinical CT does not have adequate spatial resolution to resolve the microvessels. To clinically detect changes in the function of the intramyocardial microcirculation, the spatial heterogeneity of the distribution of myocardial perfusion (F) and intramyocardial microcirculatory blood volume (Bv) was determined by perfusion CT. Two human subject groups were studied: (i) a "Control" group (24) with no risk factors nor evidence of coronary artery disease (CAD), and (ii) an "At-Risk" group (24) with hypercholesterolemia, but no evidence of CAD. In the perfusion CT image, a region of interest (ROI) covering the left ventricular myocardium was subdivided into multiple nested ROI (nROI) of equal size and used to compute F and Bv for each nROI. No significant differences between the groups were demonstrable in overall myocardial F, or Bv. The nROI data showed significantly increased spatial heterogeneity in the "At Risk" group when compared to "Control" subjects. This study demonstrates that subresolution distribution at the microcirculatory level can be quantified with myocardial perfusion CT and significant changes in these parameters occur in hypercholesterolemic subjects before they have developed significant changes in conventional perfusion parameters.
Authors:
Thomas R Behrenbeck; Cynthia H McCollough; Wayne L Miller; Eric E Williamson; Shuai Leng; Timothy L Kline; Erik L Ritman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  42     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-04-04     Completed Date:  2014-10-15     Revised Date:  2014-11-15    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Coronary Angiography*
Coronary Artery Disease / radiography*
Coronary Circulation*
Female
Humans
Hypercholesterolemia / radiography*
Male
Microcirculation*
Middle Aged
Myocardium*
Tomography, X-Ray Computed*
Grant Support
ID/Acronym/Agency:
R01 HL-72255/HL/NHLBI NIH HHS; R01 HL072255/HL/NHLBI NIH HHS; UL1 RR024150/RR/NCRR NIH HHS; UL1 TR000135/TR/NCATS NIH HHS
Comments/Corrections
Erratum In:
Ann Biomed Eng. 2014 Jun;42(6):1354

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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