Document Detail


Early blood gas abnormalities and the preterm brain.
MedLine Citation:
PMID:  20807736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors explored associations between blood gas abnormalities in more than 1,000 preterm infants during the first postnatal days and indicators of neonatal brain damage. During 2002-2004, women delivering infants before 28 weeks' gestation at one of 14 participating institutions in 5 US states were asked to enroll in the study. The authors compared infants with blood gas values in the highest or lowest quintile for gestational age and postnatal day (extreme value) on at least 1 of the first 3 postnatal days with the remainder of the subjects, with separate analyses for blood gas abnormalities on multiple days and for partial pressure of oxygen in the alveolar gas of <35. Outcomes analyzed were ventriculomegaly and an echolucent lesion on an ultrasound scan in the neonatal intensive care unit, and cerebral palsy, microcephaly, and a low score on a Bayley Scale of Infant Development at 24 months. Every blood gas derangement (hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidosis) was associated with multiple indicators of brain damage. However, for some, the associations were seen with only 1 day of exposure; others were evident with 2 or more days' exposure. Findings suggest that individual blood gas derangements do not increase brain damage risk. Rather, the multiple derangements associated with indicators of brain damage might be indicators of immaturity/vulnerability and illness severity.
Authors:
Alan Leviton; Elizabeth Allred; Karl C K Kuban; Olaf Dammann; T Michael O'Shea; Deborah Hirtz; Michael D Schreiber; Nigel Paneth;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2010-08-31
Journal Detail:
Title:  American journal of epidemiology     Volume:  172     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2010-11-02     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  907-16     Citation Subset:  IM    
Affiliation:
Neuroepidemiology Unit, Neurology Department, Children’s Hospital Boston, and Harvard Medical School, Boston, Massachusetts 02215-5724, USA. alan.leviton@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Gas Analysis
Brain / blood supply*
Brain Injuries / blood*
Cerebral Palsy / blood
Child, Preschool
Echoencephalography
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood*
United States
Grant Support
ID/Acronym/Agency:
5U01NS040069-05/NS/NINDS NIH HHS; P30-HD-18655/HD/NICHD NIH HHS
Investigator
Investigator/Affiliation:
Kristen Ecklund / ; Haim Bassan / ; Samantha Butler / ; Adré Duplessis / ; Cecil Hahn / ; Catherine Limperopoulos / ; Omar Khwaja / ; Janet S Soul / ; Bhavesh Shah / ; Frederick Hampf / ; Herbert Gilmore / ; Susan McQuiston / ; Camilia R Martin / ; Jane Share / ; Linda J Van Marter / ; Sara Durfee / ; Robert M Insoft / ; Sjirk J Westra / ; Kalpathy Krishnamoorthy / ; Cynthia Cole / ; John M Fiascone / ; Roy McCauley / ; Paige T Church / ; Cecelia Keller / ; Karen J Miller / ; Francis Bednarek / ; Jacqueline Wellman / ; Robin Adair / ; Richard Bream / ; Alice Miller / ; Albert Scheiner / ; Christy Stine / ; Richard Ehrenkranz / ; Cindy Miller / ; Nancy Close / ; Elaine Romano / ; Joanne Williams / ; T Michael O'Shea / ; Barbara Specter / ; Deborah Allred / ; Robert Dillard / ; Don Goldstein / ; Deborah Hiatt / ; Gail Hounshell / ; Ellen Waldrep / ; Lisa Washburn / ; Cherrie D Welch / ; Stephen C Engelke / ; Ira Adler / ; Sharon Buckwald / ; Rebecca Helms / ; Kathyrn Kerkering / ; Scott S MacGilvray / ; Peter Resnik / ; Carl Bose / ; Lynn A Fordham / ; Lisa Bostic / ; Diane Marshall / ; Kristi Milowic / ; Janice Wereszczak / ; Mariel Poortenga / ; Bradford W Betz / ; Steven L Bezinque / ; Joseph Junewick / ; Wendy Burdo-Hartman / ; Lynn Fagerman / ; Kim Lohr / ; Steve Pastyrnak / ; Dinah Sutton / ; Ellen Cavenagh / ; Victoria J Caine / ; Nicholas Olomu / ; Joan Price / ; Nigel Paneth / ; Padmani Karna / ; Michael D Schreiber / ; Kate Feinstein / ; Leslie Caldarelli / ; Sunila E O'Connor / ; Michael Msall / ; Susan Plesha-Troyke / ; Daniel Batton / ; Karen Brooklier / ; Beth Kring / ; Melisa J Oca / ; Katherine M Solomon / ; Joanna J Seibert / ; Robert Lorenzo /
Comments/Corrections

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