Document Detail


Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer's disease: a role for peroxisomes.
MedLine Citation:
PMID:  19749434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The central role of peroxisomes in reactive oxygen species and lipid metabolism and their importance in brain functioning are well established. The aim of this work has been to study the peroxisomal population in the Tg2576 mouse model of Alzheimer's disease (AD), at the age of three months when no apparent signs of behavioral, neuroanatomical, cytological, or biochemical alterations have been so far described. The expression and localization of peroxisomal (PMP70, CAT, AOX, and THL) and peroxisome-related proteins (PEX5p, GPX1, SOD1, and SOD2) were studied in the neocortex and hippocampus of transgenic and wild-type animals. Oxidative stress markers (TBARS, acrolein, and 8-OHG) were also evaluated. Our results demonstrate that significant alterations are already detectable at this early stage of the disease and also involve peroxisomes. Their number and protein composition change concomitantly with early oxidative stress. Interestingly, the neocortex shows a compensatory response, consisting in an increase of reactive oxygen species scavenging enzymes, while the hippocampus appears more prone to the oxidative insult. This different behavior could be related to metabolic differences in the two brain areas, also involving peroxisome abundance and/or enzymatic content.
Authors:
AnnaMaria Cimini; Sandra Moreno; Marcello D'Amelio; Loredana Cristiano; Barbara D'Angelo; Stefano Falone; Elisabetta Benedetti; Paolo Carrara; Francesca Fanelli; Francesco Cecconi; Fernanda Amicarelli; Maria Paola Cerù
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  18     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-09-16     Revised Date:  2011-11-24    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  935-52     Citation Subset:  IM    
Affiliation:
Department of Basic and Applied Biology, University of L'Aquila, 67010 L'Aquila, Italy.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism*
Animals
Blotting, Western
Brain / metabolism*
Catalase / metabolism
Disease Models, Animal
Fluorescent Antibody Technique
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mitochondria / physiology
Oxidative Stress
Peroxisomes / metabolism*
Polymerase Chain Reaction
Reactive Oxygen Species / metabolism*
Grant Support
ID/Acronym/Agency:
TCR04004//Telethon
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; EC 1.11.1.6/Catalase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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